Cornea and Refractive Surgery Department, Asociación Para Evitar la Ceguera en México, Mexico City, Mexico.
Ocul Immunol Inflamm. 2022 Jul;30(5):1123-1128. doi: 10.1080/09273948.2020.1871492. Epub 2021 Apr 1.
To present a case series of non-healing corneal ulcers treated by solid activated platelet-rich plasma (PRP) combined with silicone-hydrogel soft contact lens.
Three eyes from three patients with unresponsive corneal ulcers were included. A clot of PRP was applied directly onto the corneal ulcer and covered with a soft contact lens. The primary outcome was corneal healing. Changes in corneal ulcer area were measured by analyzing slit-lamp photographs taken using ImageJ software.
Successful corneal healing was achieved in all patients within two weeks, with no recurrences or signs of infection through the last follow-up. In two of the three cases, treatment was applied twice.
This novel procedure was easy to perform, economically advantageous, and a possible alternative to surgical approaches for enhancing epithelial wound healing in patients with non-healing corneal ulcers. Further prospective and comparative studies are needed to assess the efficacy of this treatment.
介绍一系列使用固体激活血小板丰富血浆（PRP）联合硅酮水凝胶软镜治疗的难治性角膜溃疡病例。
纳入 3 例 3 只眼的对治疗反应不佳的角膜溃疡患者。将 PRP 凝块直接涂于角膜溃疡上，并用软镜覆盖。主要结局是角膜愈合。通过分析 ImageJ 软件拍摄的裂隙灯照片来测量角膜溃疡面积的变化。
所有患者在两周内均成功愈合，末次随访时无复发或感染迹象。在这 3 例中有 2 例应用了 2 次治疗。
这种新的方法易于操作，经济实惠，可能是促进难治性角膜溃疡患者上皮伤口愈合的一种替代手术方法。需要进一步进行前瞻性和对照研究来评估这种治疗方法的疗效。
