Department of Obstetrics and Gynecology, University Hospital Salamanca, Salamanca, Spain.
Department of Obstetrics and Gynecology, General University Hospital, Valencia, Spain.
Med Ultrason. 2022 Feb 16;24(1):77-84. doi: 10.11152/mu-2961. Epub 2021 Mar 14.
The aim of this meta-analysis is to evaluate the diagnostic accuracy of three-dimensional transvaginal ultrasound subjective assessment (3D-TVS) in the preoperative detection of deep myometrial invasion (MI) in patients with endometrial cancer, using definitive frozen section diagnosis after surgery as the reference standard.
A search for studies evaluating the role of 3D-TVS for assessing myometrial invasion in endometrial cancer from January 1990 to Novem-ber 2020 was performed in PubMed/MEDLINE and Web of Science. The Quality Assessment of Diagnostic Accuracy Studies 2 evaluated the quality of the studies (QUADAS-2). All analyses were performed using MIDAS and METANDI commands.
Nine studies comprising 581 women were included. The mean prevalence of deep MI was 39.8%. QUADAS as-sessment showed that most studies had a high risk for the patient selection domain. Overall, the pooled estimated sensitivity, specificity, positive likelihood and negative likelihood ratio of 3D-TVS for detecting deep MI were 84% (95% CI, 73-90%), 82% (95% CI, 75-88%), 5 (95% CI, 3.1-7.1) and 0.20 95% CI, 0.11-0.35). respectively.
3D-TVS has an accept-able diagnostic performance for detecting MI in women with endometrial cancer.
本荟萃分析旨在评估三维经阴道超声主观评估（3D-TVS）在术前检测子宫内膜癌患者深部肌层浸润（MI）中的诊断准确性，以手术中明确的冷冻切片诊断为参考标准。
在 PubMed/MEDLINE 和 Web of Science 中检索了 1990 年 1 月至 2020 年 11 月评估 3D-TVS 在子宫内膜癌中评估肌层浸润作用的研究。采用诊断准确性研究质量评估工具 2（QUADAS-2）评估研究质量。所有分析均使用 MIDAS 和 METANDI 命令进行。
共纳入 9 项研究，包含 581 名女性。深部 MI 的平均患病率为 39.8%。QUADAS 评估显示，大多数研究在患者选择方面存在高风险。总体而言，3D-TVS 检测深部 MI 的 pooled 估计敏感性、特异性、阳性似然比和阴性似然比分别为 84%（95%CI，73-90%）、82%（95%CI，75-88%）、5（95%CI，3.1-7.1）和 0.20（95%CI，0.11-0.35）。
3D-TVS 对检测子宫内膜癌患者的 MI 具有可接受的诊断性能。
