Department of Pediatrics, Faculty of Medicine Hatay Mustafa Kemal University, Hatay, Turkey.
Department of Pediatrics, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey.
Int J Clin Pract. 2021 Jul;75(7):e14199. doi: 10.1111/ijcp.14199. Epub 2021 Apr 14.
This study aimed to investigate the association between carotid intima-media changes that play a part in the atherosclerotic process in childhood obesity and fibrin monomers as an important indicator of fibrin plaque.
This is a cross-sectional study of obese children and non-obese healthy control subjects. Height, weight, body mass index, waist/hip ratio, systolic/diastolic blood pressures were recorded, in addition, biochemistry, haemogram, fibrin monomers and d-dimer were measured in both groups. Right and left common carotid intima-media thicknesses were measured by ultrasonography and mean carotid intima-media thickness was calculated.
Obese children (n = 89, 46.1% girls, median age: 12.6 ± 2.3 years) and healthy control group (n = 40, 52.5% girls, median age: 13.2 ± 2.2 years) were comparable in terms of gender, age and puberty stage. Mean carotid intima-media thickness was higher in obese children than the healthy control group (P = .002). There was no difference between the two groups in terms of fibrin monomers and d-dimer levels. In obese children, there was a weak negative correlation between mean carotid intima-media thickness and fibrin monomers (P = .030, r = -0.233).
In obese children, mean carotid intima-media thickness was determined higher, as an early indicator of atherosclerosis. We want to emphasise that obese children are at risk for cardiovascular disease and should be evaluated in terms of atherosclerosis. This study investigates the relation between increased carotid intima-media thickness and fibrin monomers, in children, the first time in Literature.
本研究旨在探讨儿童肥胖症中动脉粥样硬化过程相关的颈动脉内膜-中层变化与纤维蛋白单体（纤维蛋白斑块的一个重要指标）之间的关系。
这是一项肥胖儿童与非肥胖健康对照组的横断面研究。记录身高、体重、体重指数、腰臀比、收缩压/舒张压，此外，两组均测量了生化指标、血常规、纤维蛋白单体和 D-二聚体。通过超声测量右左颈总动脉内膜-中层厚度，并计算平均颈动脉内膜-中层厚度。
肥胖儿童（n=89，46.1%女孩，中位数年龄：12.6±2.3 岁）和健康对照组（n=40，52.5%女孩，中位数年龄：13.2±2.2 岁）在性别、年龄和青春期阶段无差异。肥胖儿童的平均颈动脉内膜-中层厚度高于健康对照组（P=0.002）。两组纤维蛋白单体和 D-二聚体水平无差异。在肥胖儿童中，平均颈动脉内膜-中层厚度与纤维蛋白单体呈弱负相关（P=0.030，r=-0.233）。
肥胖儿童的平均颈动脉内膜-中层厚度较高，作为动脉粥样硬化的早期指标。我们想强调的是，肥胖儿童存在心血管疾病风险，应该评估其动脉粥样硬化情况。本研究首次在文献中探讨了儿童颈动脉内膜-中层厚度增加与纤维蛋白单体之间的关系。
