GM1的寡糖部分增强了S20Y神经母细胞瘤细胞的突起形成。
Oligosaccharide portion of GM1 enhances process formation by S20Y neuroblastoma cells.
作者信息
Schengrund C L, Prouty C
机构信息
Department of Biological Chemistry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
出版信息
J Neurochem. 1988 Jul;51(1):277-82. doi: 10.1111/j.1471-4159.1988.tb04867.x.
The oligosaccharide portion of ganglioside GM1 was found to enhance neuritogenesis by S20Y murine neuroblastoma cells grown in vitro. The average length of the neurites produced by cells grown in the presence of the oligosaccharide portion of GM1 was comparable to that of cells grown in the presence of intact GM1. The processes of these cells were significantly longer (p less than 0.005, pooled t test) than those of cells grown in the presence of comparable concentrations of sialic acid, lactose, sialyllactose, GD1a, or the oligosaccharide moiety of GD1a. These results suggest that it is the oligosaccharide portion of GM1 that is responsible for the ability of GM1 to enhance process outgrowth by S20Y neuroblastoma cells.
发现神经节苷脂GM1的寡糖部分可增强体外培养的S20Y小鼠神经母细胞瘤细胞的神经突生长。在GM1寡糖部分存在的情况下生长的细胞产生的神经突平均长度与在完整GM1存在的情况下生长的细胞相当。这些细胞的突起明显长于（p小于0.005，合并t检验）在相当浓度的唾液酸、乳糖、唾液酸乳糖、GD1a或GD1a的寡糖部分存在的情况下生长的细胞。这些结果表明，是GM1的寡糖部分赋予了GM1增强S20Y神经母细胞瘤细胞突起生长的能力。
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