Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Org Lett. 2021 Jul 2;23(13):4940-4944. doi: 10.1021/acs.orglett.1c00839. Epub 2021 Apr 1.
Vitamin B conjugates are broadly studied in biological sciences. As light offers spatiotemporal control, we decided to develop a method for the preparation of vitamin B conjugates that release tethered molecules upon exposure to light. Herein, we report vitamin B derivatives possessing a photolabile linker suitable for conjugation with amines, azides, and alkynes. The potential applications of such conjugates are broad and include the delivery of drugs, labels, and imaging agents to their place of action and spatiotemporal release.
维生素 B 缀合物在生物科学领域得到了广泛研究。由于光具有时空控制性，我们决定开发一种方法来制备维生素 B 缀合物，使其在暴露于光时释放连接的分子。在此，我们报告了具有光不稳定连接物的维生素 B 衍生物，该连接物适合与胺、叠氮化物和炔烃进行共轭。此类缀合物的潜在应用广泛，包括将药物、标签和成像剂递送到作用部位并进行时空释放。
