多梗死性痴呆患者脑脊液中神经元特异性烯醇化酶水平降低，但在阿尔茨海默病患者中该水平无变化。
Cerebrospinal fluid neuron-specific enolase is decreased in multi-infarct dementia, but unchanged in Alzheimer's disease.
作者信息
Sulkava R, Viinikka L, Erkinjuntti T, Roine R
机构信息
Department of Neurology, University of Helsinki, Finland.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):549-51. doi: 10.1136/jnnp.51.4.549.
Abstract
Cerebrospinal fluid (CSF) levels of neuron-specific enolase (NSE) were measured in 22 patients with probable Alzheimer's disease and in 35 patients with multi-infarct dementia, and in 15 controls. CSF NSE in patients with Alzheimer's disease did not differ from those in controls. In patients with multi-infarct dementia without recent vascular events CSF NSE was lower than in controls or in Alzheimer patients. This finding is in accord with the prevailing opinion that vascular dementia is caused by multiple infarcts and not by continuous neuronal ischaemia.
摘要
对22例可能患有阿尔茨海默病的患者、35例患有多发梗死性痴呆的患者以及15名对照者的脑脊液（CSF）中神经元特异性烯醇化酶（NSE）水平进行了检测。阿尔茨海默病患者的脑脊液NSE水平与对照者无差异。在没有近期血管事件的多发梗死性痴呆患者中，脑脊液NSE低于对照者或阿尔茨海默病患者。这一发现与普遍观点一致，即血管性痴呆是由多发性梗死引起的，而非持续性神经元缺血所致。
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