Department of Applied Mechanics, Sichuan University, Chengdu, China.
School of Civil Engineering, Southwest Jiaotong University, Chengdu, China.
Skin Pharmacol Physiol. 2021;34(3):128-134. doi: 10.1159/000514322. Epub 2021 Apr 1.
The objective of our study was to develop an optical method that instantly evaluates the stability of sclerosing foam, which would enable early predictions of the clinical performance of the foam and reduce the occurrence of clinical side effects.
Based on the principle of light scattering, we developed a method to optically test foam stability and verified it experimentally using sodium morrhuate (2 mL; 0.05 g/mL) and carbon dioxide. A self-made foam preparation instrument was used to achieve a preparation speed of 275 mm/s. The liquid-gas ratios were considered as 1:3, 1:4, and 1:5. Curves of illuminance with respect to the drainage rate and decay time were obtained. By fitting the curve, the relationship between foam half-life time (FHT) and foam decay was obtained. Thus, foam stability was evaluated using the initial illuminance value; the foam transfer time was approximately 3 s.
The experimental FHT varies between 205 and 232 s. Illuminance is exponentially related to drainage rate and linearly related with time. FHT can be expressed by the initial illuminance and illuminance curve fitting coefficients. The half-life of the foam decreases as the initial illuminance value increases, for the same sclerosing drug. The suitability of foam stability is determined by the position of the initial value in the chart.
Optical methods are feasible for evaluating foam stability over a short period of time. Clinically predicting the stability of freshly prepared foam can reduce number of incidences of further complications. This will promote the development of foam sclerotherapy and provide a basic understanding of the internal mechanical properties of foam.
本研究旨在开发一种即时评估硬化泡沫稳定性的光学方法，以便能够对泡沫的临床性能进行早期预测，并减少临床副作用的发生。
基于光散射原理，我们开发了一种光学测试泡沫稳定性的方法，并使用鲑鱼降钙素（2 mL；0.05 g/mL）和二氧化碳进行了实验验证。使用自制的泡沫制备仪器，实现了 275 mm/s 的制备速度。考虑了气液比为 1:3、1:4 和 1:5。获得了照度随排水率和衰减时间的曲线。通过拟合曲线，得到了泡沫半衰期（FHT）与泡沫衰减的关系。因此，通过初始照度值评估泡沫稳定性；泡沫传输时间约为 3 s。
实验 FHT 在 205 和 232 s 之间变化。照度与排水率呈指数关系，与时间呈线性关系。FHT 可以用初始照度值和照度曲线拟合系数来表示。对于相同的硬化药物，泡沫的半衰期随着初始照度值的增加而降低。泡沫稳定性的适用性取决于初始值在图表中的位置。
光学方法可用于在短时间内评估泡沫稳定性。临床预测新制备的泡沫的稳定性可以减少进一步并发症的发生次数。这将促进泡沫硬化疗法的发展，并为泡沫的内部力学性能提供基本了解。
