Critello Costantino Davide, Fiorillo Antonino S, Cristiano Maria Chiara, de Franciscis Stefano, Serra Raffaele
1 Department of Surgical and Medical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
2 Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Phlebology. 2019 Apr;34(3):191-200. doi: 10.1177/0268355518779844. Epub 2018 Jun 5.
Foam sclerotherapy is a clinical procedure for the treatment of unhealthy veins. The aim of this study was to investigate the effect of sulodexide (SUL) on stability of foams prepared using polidocanol (POL) and sodium tetradecyl sulfate (STS) detergents, more specifically with 0.25% aethoxysclerol and 0.2% Fibro-Vein sclerosing solutions.
Foams were produced by the Tessari method using three different weight ratios of POL-SUL and STS-SUL (1:0, 1:1, and 1:3).
The half-life of STS foams resulted as follows: 82 ± 1.6 s, 101.8 ± 2.6 s, and 109.7 ± 2.1 s for 1:0, 1:1, and 1:3 STS-SUL weight ratios, respectively. The same ratios were used for POL foams with the following results: 90.6 ± 3 s, 106.8 ± 2.6 s, and 107.6 ± 2.7 s for 1:0, 1:1, and 1:3 POL-SUL weight ratios, respectively.
The addition of SUL in sclerosing solutions can prolong the half-life of foams, and it could be potentially used as a foam stabilizer.
泡沫硬化疗法是一种治疗不健康静脉的临床方法。本研究旨在探讨舒洛地特（SUL）对使用聚多卡醇（POL）和十四烷基硫酸钠（STS）表面活性剂制备的泡沫稳定性的影响，更具体地说是对0.25%乙氧硬化醇和0.2%纤维静脉硬化溶液的影响。
采用泰萨里方法，使用三种不同重量比的POL-SUL和STS-SUL（1:0、1:1和1:3）制备泡沫。
STS泡沫的半衰期如下：1:0、1:1和1:3的STS-SUL重量比分别为82±1.6秒、101.8±2.6秒和109.7±2.1秒。POL泡沫使用相同的比例，结果如下：1:0、1:1和1:3的POL-SUL重量比分别为90.6±3秒、106.8±2.6秒和107.6±2.7秒。
在硬化溶液中添加SUL可延长泡沫的半衰期，并且它有可能用作泡沫稳定剂。
