Brands Martijn R, Sytema Jelmer, van Hulst Marinus, Kamps Arvid Wa
Paediatrics, Martini Hospital, Groningen, The Netherlands.
Clinical Pharmacy and Toxicology, Martini Hospital, Groningen, The Netherlands.
BMJ Case Rep. 2021 Apr 1;14(4):e240365. doi: 10.1136/bcr-2020-240365.
Acute intoxication with a vitamin K antagonist may cause serious coagulopathy. We report the accidental ingestion of a high dose of acenocoumarol in a young child. Two intravenous administrations of 5 mg of vitamin K, in combination with fast and repeated administration of activated charcoal and sodium sulfate, were sufficient to prevent coagulopathy and related symptoms, despite a confirmed elevated blood acenocoumarol concentration (260 µg/L).
维生素K拮抗剂急性中毒可能导致严重的凝血病。我们报告了一名幼儿意外摄入高剂量醋硝香豆素的病例。尽管已确认血液中醋硝香豆素浓度升高（260µg/L），但两次静脉注射5mg维生素K，结合快速且反复给予活性炭和硫酸钠，足以预防凝血病及相关症状。
