Medical Imaging Center, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
Department of Radiology, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang Province, China.
Aging (Albany NY). 2021 Mar 26;13(7):9948-9959. doi: 10.18632/aging.202751.
Glioma characterized by high morbidity and mortality, is one of the most common brain tumors. The application of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in differentiating glioma grading and IDH1 mutation status were poorly investigated. 78 glioma patients confirmed by pathological and imaging methods were enrolled. Glioma patients were measured using IVIM-DWI, then related parameters such as cerebral blood flow (CBF), perfusion fraction (f), pseudo diffusivity (D*), and true diffusivity (D), were derived. Receiver operating characteristic (ROC) curves were made to calculate specificity and sensitivity. The values of CBF1, CBF3, D1, rCBF1-2, rCBF3-2, and age in group high-grade gliomas (HGG) were significantly higher than that of in group low-grade gliomas (LGG). The values of CBF1, CBF3, rCBF1-2, rCBF3-2, D1, and age in group IDH1 were significantly lower than that of in group IDH1. The levels of D1 and f1 were remarkably higher in the group IDH1 than group IDH1. rCBF1-2 had a remarkably positive correlation with CBF1 (r=0.852, p<0.001). f1 showed a markedly negative correlation with CBF1 (r= -0.306, p=0.007). IVIM-DWI presented efficacy in differentiating glioma grading and IDH1 mutation status.
脑胶质瘤发病率和死亡率均较高，是最常见的脑肿瘤之一。体素内不相干运动扩散加权成像（IVIM-DWI）在鉴别胶质瘤分级和 IDH1 突变状态方面的应用研究较少。本研究纳入 78 例经病理和影像方法证实的脑胶质瘤患者，采用 IVIM-DWI 测量脑血流（CBF）、灌注分数（f）、假性扩散系数（D*）和真实扩散系数（D）等相关参数，绘制受试者工作特征（ROC）曲线计算特异性和敏感性。高级别胶质瘤（HGG）组的 CBF1、CBF3、D1、rCBF1-2、rCBF3-2 和年龄值明显高于低级别胶质瘤（LGG）组，而 CBF1、CBF3、rCBF1-2、rCBF3-2、D1 和年龄值在 IDH1 组明显低于 IDH1 组。IDH1 组 D1 和 f1 水平明显高于 IDH1 组。rCBF1-2 与 CBF1 呈显著正相关（r=0.852，p<0.001），f1 与 CBF1 呈显著负相关（r= -0.306，p=0.007）。IVIM-DWI 对鉴别胶质瘤分级和 IDH1 突变状态有一定的作用。
