在少量水分存在下阿司匹林在固态中的分解III：温度的影响及可能的机理
Decomposition of aspirin in the solid state in the presence of limited amounts of moisture III: Effect of temperature and a possible mechanism.
作者信息
Carstensen J T, Attarchi F
机构信息
School of Pharmacy, University of Wisconsin, Madison 53706.
出版信息
J Pharm Sci. 1988 Apr;77(4):318-21. doi: 10.1002/jps.2600770407.
PMID:3379589
Abstract
In a previous study, we showed that aspirin in the presence of limited amounts of moisture falls to follow Leeson-Mattocks kinetics at 62.5 degrees C. This system has been tested at a series of temperatures, and several plausible models have been tested. It is shown that the data are explained by a model in which the reaction is limited to a surface interaction between aspirin and water from the sorbed bulk moisture layer.
摘要
在之前的一项研究中，我们发现，在有限水分存在的情况下，阿司匹林在62.5摄氏度时不符合利森 - 马托克斯动力学。该体系已在一系列温度下进行了测试，并且对几种看似合理的模型也进行了测试。结果表明，数据可以用一个模型来解释，在该模型中，反应仅限于阿司匹林与吸附的大量水分层中的水之间的表面相互作用。
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