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World J Clin Oncol. 2018 Dec 20;9(8):167-171. doi: 10.5306/wjco.v9.i8.167.
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Arginine and the metabolic regulation of nitric oxide synthesis in cancer.精氨酸与癌症中一氧化氮合成的代谢调控。
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Clin Biochem. 2018 Jun;56:55-61. doi: 10.1016/j.clinbiochem.2018.04.003. Epub 2018 Apr 11.
4
Diagnostic Value of Vascular Endothelial Growth Factor, Transforming Growth Factor-β, Interleukin-8, and the Ratio of Lactate Dehydrogenase to Adenosine Deaminase in Pleural Effusion.胸腔积液中血管内皮生长因子、转化生长因子-β、白细胞介素-8 和乳酸脱氢酶与腺苷脱氨酶比值的诊断价值。
Lung. 2018 Apr;196(2):249-254. doi: 10.1007/s00408-018-0090-1. Epub 2018 Jan 20.
5
Macrophage plasticity, polarization, and function in health and disease.巨噬细胞的可塑性、极化及其在健康与疾病中的功能。
J Cell Physiol. 2018 Sep;233(9):6425-6440. doi: 10.1002/jcp.26429. Epub 2018 Mar 1.
6
Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion.血管内皮生长因子及胸腔积液中的蛋白水平用于鉴别恶性与良性胸腔积液
Oncol Lett. 2017 Sep;14(3):3657-3662. doi: 10.3892/ol.2017.6631. Epub 2017 Jul 20.
7
Malignant Pleural Effusion and ascites Induce Epithelial-Mesenchymal Transition and Cancer Stem-like Cell Properties via the Vascular Endothelial Growth Factor (VEGF)/Phosphatidylinositol 3-Kinase (PI3K)/Akt/Mechanistic Target of Rapamycin (mTOR) Pathway.恶性胸腔积液和腹水通过血管内皮生长因子（VEGF）/磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）/雷帕霉素靶蛋白（mTOR）信号通路诱导上皮-间质转化和癌症干细胞样特性。
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8
Biochemical composition of malignant ascites determines high aggressiveness of undifferentiated ovarian tumors.恶性腹水的生化组成决定了未分化卵巢肿瘤的高侵袭性。
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J Cancer Res Clin Oncol. 2016 Jun;142(6):1191-200. doi: 10.1007/s00432-016-2130-7. Epub 2016 Mar 5.

恶性胸腔积液的无细胞成分对乳腺癌细胞具有细胞毒性。

Acellular fraction from malignant effusions has cytotoxicity in breast cancer cells.

作者信息

Vargas-Villarreal Javier, Cruz-Ramos Marlid, Espino-Ojeda Alba, Gutierrez-Hermosillo Hugo, Díaz De Leon-Gonzalez Enrique, Monsivais-Diaz Ofelia, Palacios-Corona Rebeca, Martinez-Armenta Carlos Alejandro, González-Salazar Francisco, Moreno-Treviño Maria Guadalupe, Guzman-De La Garza Francisco Javier

机构信息

Centro de Investigación Biomedica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Leon 64720, Mexico.

Basic Sciences Department, School of Medicine, University of Monterrey, San Pedro Garza García, Nuevo Leon 66238, Mexico.

出版信息

Mol Clin Oncol. 2021 May;14(5):106. doi: 10.3892/mco.2021.2268. Epub 2021 Mar 20.

DOI:10.3892/mco.2021.2268
PMID:33796293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8010505/
Abstract

Malignant ascites (MA) and malignant pleural effusion (MPE) are frequently developed in patients with metastatic cancer; however, the biological properties of these fluids have not been clarified. The present study explored the biological role of a low molecular fraction derived from malignant effusions on the activation of peripheral blood mononuclear cells and on the proliferation of breast cancer cells and fibroblast 55x cells. A <10-kDa fraction from effusions of 41 oncological patients and 34 individuals without cancer was purified, and its potential role in inhibiting nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells was explored, as well as its cytotoxicity on MCF-7 breast cancer cells and fibroblast 55x cells. A significant decrease in NO production was observed in the <10-kDa fraction from malignant effusions. In addition, the acellular fraction from MA decreased the viability of breast cancer cells without affecting human fibroblasts. These data support the presence of low molecular weight molecules in malignant samples with a specific role in inhibiting the defense mechanisms of peripheral blood mononuclear cells and decreasing the viability of breast cancer cells .

摘要

恶性腹水（MA）和恶性胸腔积液（MPE）在转移性癌症患者中经常出现；然而，这些液体的生物学特性尚未阐明。本研究探讨了源自恶性积液的低分子组分对人外周血单个核细胞激活以及乳腺癌细胞和成纤维细胞55x细胞增殖的生物学作用。对41例肿瘤患者和34例非癌症个体的积液中<10 kDa的组分进行了纯化，并探讨了其对脂多糖（LPS）刺激的外周血单个核细胞中一氧化氮（NO）产生的抑制作用及其对MCF-7乳腺癌细胞和成纤维细胞55x细胞的细胞毒性。在恶性积液的<10 kDa组分中观察到NO产生显著减少。此外，MA的无细胞组分降低了乳腺癌细胞的活力，而不影响人成纤维细胞。这些数据支持恶性样本中存在低分子量分子，其在抑制外周血单个核细胞的防御机制和降低乳腺癌细胞活力方面具有特定作用。