Bao Youwei, Deng Handi, Wang Xuanhao, Zuo Hongzhi, Ma Cheng
The Department of Electronic Engineering, Tsinghua University, Beijing, 100084, China.
Beijing Innovation Center for Future Chip, Beijing, 100084, China.
Biomed Opt Express. 2021 Feb 10;12(3):1391-1406. doi: 10.1364/BOE.416406. eCollection 2021 Mar 1.
Photoacoustic (PA) imaging provides morphological and functional information about angiogenesis and thus is potentially suitable for breast cancer diagnosis. However, the development of PA breast imaging has been hindered by inadequate patients and a lack of ground truth images. Here, we report a digital breast phantom with realistic acoustic and optical properties, with which a digital PA-ultrasound imaging pipeline is developed to create a diverse pool of virtual patients with three types of masses: ductal carcinoma in situ, invasive breast cancer, and fibroadenoma. The experimental results demonstrate that our model is realistic, flexible, and can be potentially useful for accelerating the development of PA breast imaging technology.
光声（PA）成像可提供有关血管生成的形态学和功能信息，因此在乳腺癌诊断方面具有潜在适用性。然而，PA乳腺成像的发展受到患者数量不足以及缺乏真实对照图像的阻碍。在此，我们报告一种具有逼真声学和光学特性的数字乳腺体模，并据此开发了一个数字PA超声成像流程，以创建包含三种类型肿块（导管原位癌、浸润性乳腺癌和纤维腺瘤）的多样化虚拟患者库。实验结果表明，我们的模型逼真、灵活，在加速PA乳腺成像技术的发展方面可能具有潜在用途。
