Duignan Emma, O'Day Roderick, Moloney Thomas, Rahman Waheeda, Damato Bertil
Ophthalmology Department, Moorfields Eye Hospital, London, United Kingdom.
Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Ocul Oncol Pathol. 2021 Mar;7(1):48-53. doi: 10.1159/000509942. Epub 2020 Nov 10.
To define the characteristics of solitary idiopathic choroiditis (SIC) in a consecutive series of patients and propose a nomenclature change to idiopathic scleroma.
Electronic patient records were retrospectively interrogated to identify all patients diagnosed with SIC between 2002 and 2019 in a tertiary referral ophthalmic hospital in the United Kingdom.
Thirty-four eyes of 34 patients were found to have SIC. The mean age at diagnosis was 48 years (range 24-78) and 23 patients (68%) were female. All lesions were located posterior to the equator, most frequently in the inferotemporal quadrant (13 eyes, 38%). The lesions had a mean largest basal diameter of 1.2 ± 0.4 disc diameters (range 0.5-2) and their distance to the optic disc had a mean of 1.2 ± 0.9 disc diameters (range 0-3.3). All lesions were intrascleral on enhanced depth imaging optical coherence tomography, demonstrating a hypo-reflective zone within the sclera, with an underlying hyper-reflective zone in some cases. No lesion enlarged or developed features consistent with active inflammation after a median follow-up time of 0.9 years (range 0-16.8).
DISCUSSION/CONCLUSION: Optical coherence tomography shows SIC to be an intrascleral lesion. Furthermore, we found no evidence of any inflammatory component. A nomenclature change to idiopathic scleroma is appropriate to prevent unnecessary investigation.
明确一系列连续性患者中孤立性特发性脉络膜炎（SIC）的特征，并提议将其命名改为特发性巩膜炎。
对电子病历进行回顾性分析，以确定2002年至2019年期间在英国一家三级转诊眼科医院被诊断为SIC的所有患者。
34例患者的34只眼被发现患有SIC。诊断时的平均年龄为48岁（范围24 - 78岁），23例患者（68%）为女性。所有病变均位于赤道后方，最常见于颞下象限（13只眼，38%）。病变的平均最大基底直径为1.2±0.4视盘直径（范围0.5 - 2），其与视盘的距离平均为1.2±0.9视盘直径（范围0 - 3.3）。在增强深度成像光学相干断层扫描中，所有病变均位于巩膜内，显示巩膜内有一个低反射区，部分病例在其下方有一个高反射区。中位随访时间为0.9年（范围0 - 16.8年）后，无病变增大或出现与活动性炎症一致的特征。
讨论/结论：光学相干断层扫描显示SIC是一种巩膜内病变。此外，我们未发现任何炎症成分的证据。将命名改为特发性巩膜炎有助于避免不必要检查。
