Tang Ming, Bolderson Emma, O'Byrne Kenneth J, Richard Derek J
Centre for Genomics and Personalised Health, Queensland University of Technology (QUT), Brisbane, QLD, Australia.
Cancer and Ageing Research Program, Translational Research Institute, Brisbane, QLD, Australia.
Front Cell Dev Biol. 2021 Mar 16;9:626229. doi: 10.3389/fcell.2021.626229. eCollection 2021.
Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. The enhanced tumor aggressiveness stems at least partially from hypoxia-induced genomic instability. Therefore, a clear understanding of how tumor hypoxia induces genomic instability is crucial for the improvement of cancer therapeutics. This review summarizes recent developments highlighting the association of tumor hypoxia with genomic instability and the mechanisms by which tumor hypoxia drives genomic instability, followed by how hypoxic tumors can be specifically targeted to maximize efficacy.
癌症是全球主要的死亡原因之一。作为癌症的一个共同特征，缺氧与预后不良相关，这是由于肿瘤恶性程度增加和治疗耐药性增强所致。肿瘤侵袭性增强至少部分源于缺氧诱导的基因组不稳定。因此，清楚了解肿瘤缺氧如何诱导基因组不稳定对于改善癌症治疗至关重要。本综述总结了近期的研究进展，重点阐述了肿瘤缺氧与基因组不稳定的关联以及肿瘤缺氧驱动基因组不稳定的机制，接着探讨了如何特异性靶向缺氧肿瘤以实现最大疗效。
