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皮肤癣菌瘤和甲裂对甲板清创术加外用1%环吡酮胺溶液有良好反应。

Excellent Response of Dermatophytoma and Nail Splitting to Nail Plate Debridement Plus Topical Ciclopirox Olamine 1% Solution.

作者信息

Abdo Hamed Mohamed

机构信息

Department of Dermatology, Faculty of Medicine, Al Azhar University, Cairo, Egypt.

出版信息

Skin Appendage Disord. 2021 Feb;7(2):127-130. doi: 10.1159/000512037. Epub 2020 Dec 9.

Abstract

Onychomycosis often presents as thickened, discolored nails. Usually, one or both great toenails are affected. Eventually, the nail plate becomes friable and may split and break up, often due to trauma or invasion of the plate by dermatophytes that have keratolytic properties. Dermatophytoma is a unique feature of onychomycosis that occurred by abundant fungal filaments and spores forming a fungal ball under the nail plate. It is often refractory to traditional therapy. Based on the clinical and mycological examination, a case of onychomycosis in a 45-year-old woman presented as dermatophytoma with longitudinal nail splitting caused by is presented. The case was successfully treated with nail plate debridement plus topical ciclopirox olamine 1% solution. Nail debridement was performed using a 15-scalpel blade to remove the affected nail portion with the underlying subungual debris to enhance the effect of topical ciclopirox 1% solution which was then applied 3 times daily to the debrided area. Follow-up visits with nail photography were planned every 2 weeks after the procedure to check treatment progress. A complete clinical resolution was achieved after 5 months. This treatment option can be advocated for similar nail conditions avoiding unnecessary and expensive lines of treatment.

摘要

甲癣通常表现为指甲增厚、变色。通常,一个或两个大脚趾甲会受到影响。最终,甲板会变得易碎,可能会裂开并破碎,这通常是由于具有角质溶解特性的皮肤癣菌对甲板的创伤或侵入所致。皮肤癣菌瘤是甲癣的一个独特特征,它是由丰富的真菌丝和孢子在甲板下形成真菌球而发生的。它通常对传统治疗有抗性。基于临床和真菌学检查,报告了一例45岁女性的甲癣病例,该病例表现为皮肤癣菌瘤并伴有由……引起的指甲纵向裂开。该病例通过甲板清创术加外用1%环吡酮胺溶液成功治疗。使用15号手术刀刀片进行指甲清创,以去除受影响的指甲部分及其下方的甲下碎屑,以增强外用1%环吡酮溶液的效果,然后每天3次将其应用于清创区域。术后计划每2周进行一次随访并拍摄指甲照片,以检查治疗进展。5个月后实现了完全临床治愈。对于类似的指甲状况,可以提倡这种治疗选择,避免不必要且昂贵的治疗方法。

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本文引用的文献

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Treatment and management strategies of onychomycosis.甲真菌病的治疗和管理策略。
J Mycol Med. 2020 Jun;30(2):100949. doi: 10.1016/j.mycmed.2020.100949. Epub 2020 Mar 14.
7
Dermatophytoma: description of 7 cases.皮肤癣菌瘤:7例病例描述
J Am Acad Dermatol. 2012 Jun;66(6):1014-6. doi: 10.1016/j.jaad.2010.06.034.
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Prognostic factors for cure following treatment of onychomycosis.治疗甲真菌病后治愈的预后因素。
J Eur Acad Dermatol Venereol. 2010 Jun;24(6):679-84. doi: 10.1111/j.1468-3083.2009.03487.x. Epub 2009 Nov 19.
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Topical treatments for fungal infections of the skin and nails of the foot.足部皮肤和指甲真菌感染的局部治疗方法。
Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD001434. doi: 10.1002/14651858.CD001434.pub2.

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