Department of Dermatology, University of Iceland, Reykjavik, Iceland.
J Eur Acad Dermatol Venereol. 2010 Jun;24(6):679-84. doi: 10.1111/j.1468-3083.2009.03487.x. Epub 2009 Nov 19.
To examine if host baseline factors and week 24 mycology results are associated with mycological and clinical cure in patients with onychomycosis treated with oral terbinafine.
Open pilot study to determine prognostic factors in the treatment of onychomycosis.
Outpatient dermatology clinic.
A total of 199 patients from the Icelandic arm of a trial comparing continuous terbinafine with intermittent terbinafine in onychomycosis were recruited for additional observation.
Mycological, clinical and complete cure of the target toenail 72 weeks after treatment was initiated.
Patients with matrix involvement or slow nail growth were less likely to reach mycological, clinical and complete cure. Lateral involvement affected complete and mycological cure rates negatively. Patients with a dermatophytoma were less likely to reach mycological cure. Patients with a history of prior infection, men and older patients were less likely to reach clinical cure. Positive culture at 24 weeks affected mycological and clinical cure at 72 weeks negatively.
Only patients treated with terbinafine were considered.
Several host-related factors at baseline and positive culture at 24 weeks had negative effects on cure of onychomycosis 72 weeks after treatment was initiated. This finding merits a large study on prognostic outcome factors in onychomycosis.
研究宿主基线因素和第 24 周的真菌学结果与口服特比萘芬治疗甲真菌病患者的真菌学和临床治愈是否相关。
开放性初步研究，以确定甲真菌病治疗中的预后因素。
皮肤科门诊。
共招募了来自冰岛分部的 199 名参加特比萘芬连续与间歇治疗甲真菌病试验的患者进行额外观察。
治疗开始后 72 周时的真菌学、临床和目标趾甲完全治愈。
有基质受累或指甲生长缓慢的患者更不可能达到真菌学、临床和完全治愈。甲侧缘受累对完全和真菌学治愈率有负面影响。有甲真菌瘤的患者更不可能达到真菌学治愈。有既往感染史、男性和老年患者更不可能达到临床治愈。24 周时的阳性培养对 72 周时的真菌学和临床治愈有负面影响。
仅考虑了接受特比萘芬治疗的患者。
治疗开始后 72 周时，宿主相关的一些基线因素和 24 周时的阳性培养对甲真菌病的治愈有负面影响。这一发现值得对甲真菌病的预后因素进行更大规模的研究。
