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在一项暴露前预防随机安慰剂对照试验（ANRS-IPERGAY）中血清转化者早期治疗期间的炎症标志物

Inflammatory Markers During Early Treatment of Seroconverters in a Randomized Placebo-Controlled Trial of PrEP (ANRS-IPERGAY).

作者信息

Chawki Sylvain, Charreau Isabelle, Gabassi Audrey, Carette Diane, Cua Eric, Cotte Laurent, Pialoux Gilles, Pintado Claire, Meyer Laurence, Chaix Marie-Laure, Delaugerre Constance, Molina Jean-Michel

机构信息

Department of Virology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.

INSERM U944, Paris University, Paris, France.

出版信息

Open Forum Infect Dis. 2021 Mar 20;8(3):ofab085. doi: 10.1093/ofid/ofab085. eCollection 2021 Mar.

DOI:10.1093/ofid/ofab085
PMID:33796598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7990514/
Abstract

HIV-related inflammation is associated with poor outcomes. We describe inflammatory biomarkers in 17 participants in a pre-exposure prophylaxis trial who seroconverted with very early initiation of antiretroviral therapy. Inflammation peaked at the time of HIV infection and returned to baseline within 6-12 months. Starting antiretroviral therapy very early could help mitigate long-lasting HIV-related inflammation.

摘要

与HIV相关的炎症与不良预后相关。我们描述了17名参与暴露前预防试验的参与者的炎症生物标志物，这些参与者在极早期开始抗逆转录病毒治疗后发生了血清转化。炎症在HIV感染时达到峰值，并在6至12个月内恢复到基线水平。极早期开始抗逆转录病毒治疗可能有助于减轻长期的HIV相关炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a990/7990514/bb55d11aaa90/ofab085_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a990/7990514/bb55d11aaa90/ofab085_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a990/7990514/bb55d11aaa90/ofab085_fig1.jpg

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本文引用的文献

1
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急性HIV感染期开始抗逆转录病毒治疗的患者中存在持续的慢性炎症，尽管炎症程度有所减轻。
Clin Infect Dis. 2017 Jan 15;64(2):124-131. doi: 10.1093/cid/ciw683. Epub 2016 Oct 12.
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On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection.按需暴露前预防治疗在 HIV-1 感染高危男性中的应用。
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Lancet. 2016 Jan 2;387(10013):53-60. doi: 10.1016/S0140-6736(15)00056-2. Epub 2015 Sep 9.
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Pre-therapy inflammation and coagulation activation and long-term CD4 count responses to the initiation of antiretroviral therapy.治疗前炎症和凝血激活以及对抗逆转录病毒治疗开始的长期CD4细胞计数反应。
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Prevention of HIV-1 infection with early antiretroviral therapy.早期抗逆转录病毒疗法预防 HIV-1 感染。
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