Van Every M J, Sago A L, Ehler W J, Novicki D E
Department of Urology, Wilford Hall United States Air Force Medical Center, Lackland AFB, Texas.
J Urol. 1988 Jul;140(1):188-90. doi: 10.1016/s0022-5347(17)41524-2.
Superficial transitional cell carcinoma of the bladder has a 50 to 70% recurrence rate. Recurrences may be related to tumor cell implantation during transurethral resection which disrupts the glycosaminoglycan layer of the bladder. This study demonstrated decreased tumor formation in murine bladders which were pre-treated with sucralfate, a synthetic glycosaminoglycan, prior to tumor cell instillation. These results suggest a possible role for sucralfate as a glycosaminoglycan supplement.
膀胱浅表性移行细胞癌的复发率为50%至70%。复发可能与经尿道切除术中肿瘤细胞种植有关，这会破坏膀胱的糖胺聚糖层。本研究表明，在向小鼠膀胱内注入肿瘤细胞之前，用合成糖胺聚糖硫糖铝进行预处理，可减少肿瘤形成。这些结果提示硫糖铝作为一种糖胺聚糖补充剂可能具有一定作用。
