Bulbul M A, Chin J L, Huben R P, Englander L S, Pontes J E
J Urol. 1985 Dec;134(6):1231-5. doi: 10.1016/s0022-5347(17)47701-9.
Nitrofurans compounds and derivatives demonstrate antineoplastic activity in vitro as well as in vivo. Nitrofurantoin caused in vitro growth inhibition of a FANFT-induced murine bladder tumor (MBT2) and a human transitional cell carcinoma cell line (GIBB) in concentrations of 125 microM, 250 microM and 500 microM. The implantation and growth of MBT2 in the cauterized mouse bladder was inhibited by 250 microM nitrofurantoin. The bladder mucosa of two groups of C3Hf/HeHa female mice was electrically cauterized. In group I, 1 X 10(6) MBT2 cells were injected into the bladders of 42 mice, while in group II 1 X 10(6) MBT2 cells in 250 microM nitrofurantoin solution were injected into the bladders of 51 mice. Positive tumor implantation was seen in 25 bladders (59.5 per cent) of group I as compared to 15 bladders (29.5 per cent) of group II. All tumors in group I were large, occupying more than 50 per cent of bladder cross sectional area with 24 per cent showing extravesical extention. Sixty-six per cent of tumors in groups II were less than 25 per cent of bladder cross sectional area and 13.4 per cent had extravesical extention.
硝基呋喃类化合物及其衍生物在体外和体内均表现出抗肿瘤活性。呋喃妥因在浓度为125微摩尔/升、250微摩尔/升和500微摩尔/升时，对FANFT诱导的小鼠膀胱肿瘤（MBT2）和人移行细胞癌细胞系（GIBB）具有体外生长抑制作用。250微摩尔/升的呋喃妥因可抑制MBT2在烧灼过的小鼠膀胱中的植入和生长。对两组C3Hf/HeHa雌性小鼠的膀胱黏膜进行电烧灼。在第一组中，将1×10⁶个MBT2细胞注射到42只小鼠的膀胱中，而在第二组中，将1×10⁶个MBT2细胞加入250微摩尔/升的呋喃妥因溶液中，注射到51只小鼠的膀胱中。第一组25个膀胱（59.5%）出现阳性肿瘤植入，而第二组为15个膀胱（29.5%）。第一组所有肿瘤都很大，占据膀胱横截面积的50%以上，24%的肿瘤有膀胱外扩展。第二组66%的肿瘤小于膀胱横截面积的25%，13.4%有膀胱外扩展。
