Belikov Aleksey V, Talay Angelo, de Magalhães João Pedro
Genomics of Ageing and Rejuvenation Lab, Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
NPJ Aging. 2025 May 19;11(1):37. doi: 10.1038/s41514-025-00229-w.
The DrugAge database serves as a comprehensive resource for studying compounds that increase lifespan in model organisms. In the latest version of DrugAge, we implemented multiple updates, predominantly focusing on mouse studies to enhance data accuracy and consistency. Key improvements include re-recording of mouse data from original sources, standardization of drug dosages to parts per million, and recording of administration routes, treatment initiation ages, and lifespans of controls. The user interface was also upgraded. Additionally, weight change data were included to address the potential impact of caloric restriction induced by drug administration on lifespan. Our analysis revealed significant correlations between weight loss and lifespan extension in male mice, particularly in studies conducted by the Interventions Testing Program, highlighting the importance of considering weight changes in lifespan studies. We also observed notable sex-related differences in lifespan and weight change responses, underscoring the need for sex-specific analyses in aging research.
DrugAge数据库是研究可延长模式生物寿命的化合物的综合资源。在DrugAge的最新版本中，我们进行了多项更新，主要集中在小鼠研究上，以提高数据的准确性和一致性。主要改进包括从原始来源重新记录小鼠数据、将药物剂量标准化为百万分之一、记录给药途径、治疗起始年龄和对照组的寿命。用户界面也进行了升级。此外，还纳入了体重变化数据，以解决药物给药引起的热量限制对寿命的潜在影响。我们的分析表明，雄性小鼠体重减轻与寿命延长之间存在显著相关性，特别是在干预测试计划进行的研究中，这突出了在寿命研究中考虑体重变化的重要性。我们还观察到寿命和体重变化反应存在显著的性别差异，强调了在衰老研究中进行性别特异性分析的必要性。
