Shea M Kyla, Lynch S Delanie, Brinkley Tina E, Kritchevsky Stephen B
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States.
Center for Injury Biomechanics, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Curr Dev Nutr. 2025 Jun 18;9(7):107485. doi: 10.1016/j.cdnut.2025.107485. eCollection 2025 Jul.
As the global population of older adults increases, identifying strategies that modify biological aging has become an increasing priority for improving health span and lifespan. When coupled with the growing epidemic of overweight and obesity, nutritional strategies have garnered considerable research attention due to their potential to modulate both aging and metabolism at the cellular and molecular levels. Several key nutritional influences are currently being studied for their effects on aging biology, including caloric restriction, protein restriction, time-restricted eating, ketosis, and the gut microbiome. Of particular relevance is the role of dietary interventions in older adults with obesity, which must carefully balance the cardiometabolic benefits of weight loss with the unintended musculoskeletal losses, including muscle and bone mass. To discuss these critical issues, the Research Centers Collaborative Network sponsored a 1.5-d multidisciplinary workshop bringing together basic, clinical, and translational scientists in the fields of nutrition and aging biology. This meeting included sessions on calorie and protein restriction, timing of food intake, the gut microbiome, and obesity treatment for older adults. The agenda and recordings are archived at https://www.rccn-aging.org/nutrition-and-aging-biology. In this article, we describe the workshop's themes and discussions and highlight research gaps that, if filled, will considerably advance our understanding of the role of nutrition in healthy aging.
随着全球老年人口的增加，确定能够改变生物衰老的策略已成为改善健康寿命和寿命的日益重要的优先事项。再加上超重和肥胖的流行日益严重，营养策略因其在细胞和分子水平上调节衰老和新陈代谢的潜力而受到了大量的研究关注。目前正在研究几种关键的营养因素对衰老生物学的影响，包括热量限制、蛋白质限制、限时进食、生酮作用以及肠道微生物群。特别相关的是饮食干预在老年肥胖患者中的作用，这必须在减肥对心脏代谢的益处与包括肌肉和骨量在内的意外肌肉骨骼损失之间仔细权衡。为了讨论这些关键问题，研究中心协作网络主办了一次为期1.5天的多学科研讨会，汇集了营养和衰老生物学领域的基础、临床和转化科学家。这次会议包括关于热量和蛋白质限制、食物摄入时间、肠道微生物群以及老年肥胖症治疗的会议。议程和录音存档于https://www.rccn-aging.org/nutrition-and-aging-biology。在本文中，我们描述了研讨会的主题和讨论内容，并强调了一些研究空白，如果填补这些空白，将大大推进我们对营养在健康衰老中的作用的理解。
