Carey P O, Howards S S, Vance M L
Department of Urology, University of Virginia Medical School, Charlottesville.
J Urol. 1988 Jul;140(1):76-9. doi: 10.1016/s0022-5347(17)41491-1.
Hypogonadism, either primary or secondary, results in diminished libido and/or impotence. Conventional treatment consists of periodic intramuscular injections (usually bimonthly) of a depot testosterone preparation or daily oral ingestion of methyl testosterone. These conventional treatments may be associated with side effects, such as gynecomastia, liver function abnormalities and edema. A new method of administering testosterone is by daily application of a transdermal therapeutic system. We studied the efficacy and safety of the transdermal therapeutic system in 4 hypogonadal men. Three patients were treated for 12 weeks and 1 for 7 weeks, and they were evaluated weekly. Of 4 patients 3 had improvement in erectile and/or sexual function. Mean plasma testosterone levels increased significantly compared to pre-treatment values during 7 of 12 treatment weeks. There were no adverse effects of the transdermal therapeutic system as indicated by serial physical examinations, daily reports, blood chemistry studies, liver function tests, urinalysis and hematological profiles. This preliminary report of transdermal testosterone delivery indicates that it may provide an effective alternative method of gonadal steroid replacement.
原发性或继发性性腺功能减退都会导致性欲减退和/或阳痿。传统治疗方法包括定期肌肉注射（通常每两个月一次）长效睾酮制剂或每日口服甲基睾酮。这些传统治疗可能会伴有副作用，如乳腺增生、肝功能异常和水肿。一种新的睾酮给药方法是每日使用经皮治疗系统。我们研究了经皮治疗系统在4名性腺功能减退男性中的疗效和安全性。3名患者接受了12周的治疗，1名患者接受了7周的治疗，并且每周对他们进行评估。4名患者中有3名的勃起和/或性功能得到改善。与治疗前的值相比，在12个治疗周中的7周，平均血浆睾酮水平显著升高。连续的体格检查、每日报告、血液化学研究、肝功能测试、尿液分析和血液学检查均未显示经皮治疗系统有不良反应。这份关于经皮睾酮给药的初步报告表明，它可能提供一种有效的性腺类固醇替代方法。
