Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Vet Surg. 2021 Jul;50(5):990-998. doi: 10.1111/vsu.13627. Epub 2021 Apr 1.
To compare efficacy and safety of a continuous rate infusion of detomidine hydrochloride and romifidine hydrochloride for standing elective bilateral laparoscopic ovariectomy in mares.
Blinded, randomized prospective clinical study.
Eighteen healthy mares presenting for elective bilateral ovariectomy METHODS: Mares were randomly assigned to one of two sedation protocols. Prior to surgery, baseline head height, heart rate, respiratory rate, and postural sway were recorded. An IV loading dose of α2-agonist (46 μg/kg romifidine or 13.9 μg/kg detomidine) was administered. Standing sedation was maintained with a continuous rate infusion of the respective α2-agonist (126 μg/kg/h romifidine or 37.8 μg/kg/h detomidine). Intraoperative measurements included respiratory rate, heart rate, head height, postural sway, and response to surgical stimulus. Postoperatively, fecal output was recorded, and pain scoring was performed using composite pain score and visual analog scales.
Three of 18 horses required additional α-2 agonists: one detomidine and two romifidine and butorphanol. Head height during surgery was lower (p < .001) in mares receiving detomidine. Postural sway around the vertical axis was greater in mares sedated with detomidine rather than romifidine (p = .013). No differences were detected in intraoperative heart rate, postoperative pain scores or postoperative fecal output between sedation techniques.
Comparable scores for surgical stimulation and sedation were measured in both sedation groups. No differences in postoperative analgesia or manure production were identified.
Romifidine appears suitable as an alternative to detomidine and may limit ataxia and head drop in sedated horses.
比较盐酸右美托咪定和盐酸罗米非定持续输注用于马站立式双侧腹腔镜卵巢切除术的疗效和安全性。
双盲、随机前瞻性临床研究。
18 匹健康的母马，行双侧卵巢切除术。
母马随机分配到两种镇静方案之一。手术前记录基线头高、心率、呼吸频率和姿势摆动。静脉注射α2 激动剂（46μg/kg 罗米非定或 13.9μg/kg 盐酸右美托咪定）负荷剂量。以各自的α2 激动剂（126μg/kg/h 罗米非定或 37.8μg/kg/h 盐酸右美托咪定）持续输注维持站立镇静。术中测量包括呼吸频率、心率、头高、姿势摆动和对手术刺激的反应。术后记录粪便排出量，并使用复合疼痛评分和视觉模拟评分进行疼痛评分。
18 匹马中有 3 匹马需要额外的α-2 激动剂：1 匹马使用盐酸右美托咪定，2 匹马使用盐酸罗米非定和布托啡诺。接受盐酸右美托咪定镇静的马在手术中头高较低（p<0.001）。与使用盐酸罗米非定相比，使用盐酸右美托咪定镇静的马在垂直轴周围的姿势摆动更大（p=0.013）。两种镇静技术之间术中心率、术后疼痛评分或术后粪便排出量无差异。
在两种镇静组中测量到相似的手术刺激和镇静评分。在术后镇痛或粪便产生方面没有发现差异。
罗米非定似乎可作为盐酸右美托咪定的替代品，可减少镇静马的共济失调和低头。
