Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, India.
Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal (Sonipat) 131039, Haryana, India.
Curr Drug Deliv. 2022;19(2):170-181. doi: 10.2174/1567201818666210331123022.
Unprincipled use of antibiotics has led to antimicrobial resistance (AMR) against mostly available compounds, and has now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico- chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms, which make them potential candidates against AMR. Green synthesis of AgNPs using various medicinal plants has demonstrated a broader spectrum of action against several microbes in a number of attempts. The present paper provides an insight into the scientific studies that have elucidated the positive role of plant extracts/phytochemicals during the green synthesis of AgNPs and their future perspectives. The studies conducted so far seem promising; still, a few factors like the precise mechanism of action of AgNPs, their synergistic interaction with biomolecules, and industrial scalability, need to be explored further till effective drug development using green synthesized AgNPs in healthcare systems against AMR is established.
不规范使用抗生素导致大多数现有化合物产生了抗微生物药物耐药性（AMR），现在已经成为科学界关注的主要问题。然而，在过去十年中，由于其独特的物理化学性质，绿色合成的银纳米粒子（AgNPs）在开发新型抗菌疗法方面受到了更多关注。与传统抗生素不同，AgNPs 通过多种机制发挥作用，这使它们成为对抗 AMR 的潜在候选药物。使用各种药用植物进行绿色合成 AgNPs 的研究已经在多次尝试中展示了对多种微生物的更广泛的作用谱。本文提供了对阐明植物提取物/植物化学物质在绿色合成 AgNPs 过程中积极作用的科学研究的深入了解，以及它们的未来前景。到目前为止进行的研究似乎很有希望；但是，仍有一些因素需要进一步探索，例如 AgNPs 的精确作用机制、它们与生物分子的协同相互作用以及工业可扩展性，直到在医疗保健系统中使用绿色合成的 AgNPs 对抗 AMR 建立有效的药物开发。
