Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Department of Medicine, University of Calgary, Calgary, Canada.
J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):9-16. doi: 10.1097/MPG.0000000000003140.
Electrogastrography (EGG) is a non-invasive method of measuring gastric electrophysiology. Abnormal gastric electrophysiology is thought to contribute to disease pathophysiology in patients with gastroduodenal symptoms but this has not been comprehensively quantified in pediatric populations. This study aimed to quantify the abnormalities in gastric electrophysiology on EGG in neonatal and pediatric patients.Databases were systematically searched for articles utilizing EGG in neonatal and pediatric patients (≤18 years). Primary outcomes were prevalence of abnormality, percentage of time in normal rhythm, and power ratio. Secondary outcomes were correlations between patient symptoms and abnormal gastric electrophysiology on EGG.A total of 33 articles (1444 participants) were included. EGG methodologies were variable. Pooled prevalence of abnormalities on EGG ranged from 61% to 86% in patients with functional dyspepsia (FD), gastro-esophageal reflux disease (GERD), and type 1 diabetes mellitus (T1DM). FD patients averaged 20.8% (P = 0.011) less preprandial and 21.6% (P = 0.031) less postprandial time in normogastria compared with controls. Electrophysiological abnormalities were inconsistent in GERD. T1DM patients averaged 46.2% (P = 0.0003) less preprandial and similar (P = 0.32) postprandial time in normogastria compared with controls, and had a lower power ratio (SMD -2.20, 95% confidence interval [CI]: -4.25 to -0.15; P = 0.036). Symptom correlations with gastric electrophysiology were inconsistently reported.Abnormalities in gastric electrophysiology were identifiable across a range of pediatric patients with gastroduodenal symptoms on meta-analysis. However, techniques have been inconsistent, and standardized and more reliable EGG methods are desirable to further define these findings and their potential utility in clinical practice.
胃电图（EGG）是一种测量胃电生理的非侵入性方法。异常的胃电生理被认为有助于胃十二指肠症状患者的疾病病理生理学，但这在儿科人群中尚未得到全面量化。本研究旨在量化新生儿和儿科患者胃电图上胃电生理的异常。系统地检索了利用胃电图的新生儿和儿科患者（≤18 岁）的文章。主要结局是异常的患病率、正常节律的时间百分比和功率比。次要结局是患者症状与胃电图异常之间的相关性。共纳入 33 篇文章（1444 名参与者）。EGG 方法学各不相同。功能性消化不良（FD）、胃食管反流病（GERD）和 1 型糖尿病（T1DM）患者的胃电图异常患病率从 61%到 86%不等。FD 患者餐前和餐后正常胃节律的时间分别比对照组少 20.8%（P=0.011）和 21.6%（P=0.031）。GERD 患者的电生理异常不一致。T1DM 患者餐前和餐后正常胃节律的时间分别比对照组少 46.2%（P=0.0003）和相似（P=0.32），功率比也较低（SMD-2.20，95%置信区间[CI]：-4.25 至-0.15；P=0.036）。胃电生理与症状的相关性报告不一致。在荟萃分析中，胃十二指肠症状的一系列儿科患者中可识别出胃电生理异常。然而，技术一直不一致，需要标准化和更可靠的 EGG 方法来进一步确定这些发现及其在临床实践中的潜在用途。
