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TDP-43 interacts with pathological τ protein in Alzheimer's disease.

作者信息

Tomé Sandra O, Gomes Luis A, Li Xiaohang, Vandenberghe Rik, Tousseyn Thomas, Thal Dietmar Rudolf

机构信息

Department of Imaging and Pathology, Laboratory of Neuropathology, Leuven Brain Institute, KU-Leuven, O&N IV, Herestraat 49, box 1032, 3000, Leuven, Belgium.

Department of Neurosciences, Laboratory of Cognitive Neurology, Leuven Brain Institute, KU-Leuven, Leuven, Belgium.

出版信息

Acta Neuropathol. 2021 May;141(5):795-799. doi: 10.1007/s00401-021-02295-2. Epub 2021 Apr 2.

DOI:10.1007/s00401-021-02295-2
PMID:33797585
Abstract
摘要

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本文引用的文献

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Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes.针对 TDP-43 在丝氨酸 375 处磷酸化的抗体表明 FTLD-TDP 亚型中 TDP-43 聚集物的构象差异。
Acta Neuropathol. 2020 Nov;140(5):645-658. doi: 10.1007/s00401-020-02207-w. Epub 2020 Aug 10.
2
Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes.阿尔茨海默病中 TDP-43 病理学的独特分子模式：与临床表型的关系。
Acta Neuropathol Commun. 2020 Apr 29;8(1):61. doi: 10.1186/s40478-020-00934-5.
3
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.
海马亚区：阿尔茨海默病和帕金森病中的体积、神经病理学易损性及认知衰退
Alzheimers Res Ther. 2025 May 30;17(1):121. doi: 10.1186/s13195-025-01768-w.
4
Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers.阿尔茨海默病神经病理学及其通过体液和影像生物标志物进行的评估。
Mol Neurodegener. 2025 Mar 14;20(1):33. doi: 10.1186/s13024-025-00819-y.
5
Assessing Co-Localization of ITM2B With Alzheimer's Disease and Limbic-Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Changes.评估ITM2B与阿尔茨海默病以及边缘叶为主的年龄相关性TDP-43脑病神经病理变化的共定位情况。
Neuropathology. 2025 Aug;45(4):e70003. doi: 10.1111/neup.70003. Epub 2025 Mar 5.
6
Role of tau versus TDP-43 pathology on medial temporal lobe atrophy in aging and Alzheimer's disease.tau蛋白与TDP-43病理学在衰老和阿尔茨海默病中对内侧颞叶萎缩的作用
Alzheimers Dement. 2025 Feb;21(2):e14582. doi: 10.1002/alz.14582.
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Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair.与神经退行性疾病相关的蛋白质：与DNA修复的联系
Biomedicines. 2024 Dec 11;12(12):2808. doi: 10.3390/biomedicines12122808.
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pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates.TAU58小鼠视网膜中的pTau病理学：与神经节细胞变性的关联以及对来自人脑裂解物的pTau播种和传播的影响。
Acta Neuropathol Commun. 2024 Dec 20;12(1):194. doi: 10.1186/s40478-024-01907-8.
9
Co-Aggregation of TDP-43 with Other Pathogenic Proteins and Their Co-Pathologies in Neurodegenerative Diseases.TDP-43 与其他致病蛋白的共聚集及其在神经退行性疾病中的共病理学。
Int J Mol Sci. 2024 Nov 18;25(22):12380. doi: 10.3390/ijms252212380.
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Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.纯 LATE-NC：频率、临床影响，以及在评估这种和其他非阿尔茨海默病病理亚型时考虑 APOE 基因型的重要性。
Acta Neuropathol. 2024 Nov 15;148(1):66. doi: 10.1007/s00401-024-02821-y.
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Neuropathology. 2009 Oct;29(5):566-73. doi: 10.1111/j.1440-1789.2009.01017.x. Epub 2009 Apr 21.
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