Jeong H W, Kim M K, Yi H J, Kim D M, Jeon S J, Lee H K, Oh Y H, Hwang Y O
Seoul Metropolitan Government Research Institute of Public Health and Environment, Gyeonggi-do, Korea.
Lett Appl Microbiol. 2021 Jul;73(1):107-112. doi: 10.1111/lam.13482. Epub 2021 May 5.
Jogaejeot, seasoned Venerupis philippinarum, is a traditional Korean fermented food, and hepatitis A virus (HAV) can be transmitted through contaminated food, especially bivalve shellfish, causing acute gastroenteritis worldwide. Here, we carried out a phylogenetic analysis to identify and characterize HAV strains in jogaejeot samples associated with hepatitis A (HA) outbreaks in Seoul, South Korea, in 2019. The HAV strains were identified using blast and molecular analysis of the amplified HAV VP1-P2B genome region. The HAV strains identified in the five jogaejeot samples shared at least 99% sequence identity, were all classified as genotype IA and were most closely related to strains that are widespread in East Asia. These results support a link between the consumption of jogaejeot and the HA outbreaks observed in 2019 in Seoul. In addition, they indicate a need for more stringent enforcement of food safety regulations for the shellfish industry, especially against HAV, and the value of widespread vaccination.
腌渍菲律宾蛤仔（Jogaejeot）是一种传统的韩国发酵食品，甲型肝炎病毒（HAV）可通过受污染的食物传播，尤其是双壳贝类，在全球范围内引发急性肠胃炎。在此，我们进行了系统发育分析，以鉴定和表征2019年韩国首尔与甲型肝炎（HA）疫情相关的腌渍菲律宾蛤仔样本中的HAV毒株。通过对扩增的HAV VP1 - P2B基因组区域进行blast和分子分析来鉴定HAV毒株。在五个腌渍菲律宾蛤仔样本中鉴定出的HAV毒株序列同一性至少为99%，均被归类为IA基因型，并且与在东亚广泛传播的毒株关系最为密切。这些结果支持了食用腌渍菲律宾蛤仔与2019年首尔观察到的HA疫情之间的联系。此外，它们表明需要对贝类行业更严格地执行食品安全法规，特别是针对HAV，以及广泛接种疫苗的价值。
