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光纤在无标记生物传感器和生物成像中的应用：综述。

Applications of Optical Fiber in Label-Free Biosensors and Bioimaging: A Review.

机构信息

Translational Biophotonics Laboratory, Institute of Bioengineering and Bioimaging, Agency for Science, Technology and Research (A*STAR), Singapore 138667, Singapore.

出版信息

Biosensors (Basel). 2022 Dec 30;13(1):64. doi: 10.3390/bios13010064.

DOI:10.3390/bios13010064
PMID:36671899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9855469/
Abstract

Biosensing and bioimaging are essential in understanding biological and pathological processes in a living system, for example, in detecting and understanding certain diseases. Optical fiber has made remarkable contributions to the biosensing and bioimaging areas due to its unique advantages of compact size, immunity to electromagnetic interference, biocompatibility, fast response, etc. This review paper will present an overview of seven common types of optical fiber biosensors and optical fiber-based ultrasound detection in photoacoustic imaging (PAI) and the applications of these technologies in biosensing and bioimaging areas. Of course, there are many types of optical fiber biosensors. Still, this paper will review the most common ones: optical fiber grating, surface plasmon resonance, Sagnac interferometer, Mach-Zehnder interferometer, Michelson interferometer, Fabry-Perot Interferometer, lossy mode resonance, and surface-enhanced Raman scattering. Furthermore, different optical fiber techniques for detecting ultrasound in PAI are summarized. Finally, the main challenges and future development direction are briefly discussed.

摘要

生物传感和生物成像对于理解活体系统中的生物和病理过程至关重要，例如，用于检测和理解某些疾病。由于光纤具有尺寸紧凑、抗电磁干扰、生物相容性、快速响应等独特优势，因此在生物传感和生物成像领域做出了重要贡献。本文综述了七种常见类型的光纤生物传感器和基于光纤的超声检测在光声成像（PAI）中的应用，以及这些技术在生物传感和生物成像领域的应用。当然，光纤生物传感器有很多种。但是，本文将重点介绍最常见的几种：光纤光栅、表面等离子体共振、萨格纳克干涉仪、马赫-曾德尔干涉仪、迈克尔逊干涉仪、法布里-珀罗干涉仪、损耗模式共振和表面增强拉曼散射。此外，还总结了用于检测 PAI 中超声的不同光纤技术。最后，简要讨论了主要挑战和未来的发展方向。

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