Lin Yu-Fang, Jin Xiao-Qing, Zhu Jian-Fang, Chen Yi-Dan, Sheng Ji-Li, He Jiao-Jun, Jin Yuan-Yuan
Department of Acupuncture and Moxibustion, Zhejiang Hospital, Hangzhou 310013, China.
Zhongguo Zhen Jiu. 2021 Mar 12;41(3):269-74. doi: 10.13703/j.0255-2930.20200210-k0001.
To observe the effect of ginger-separated moxibustion on fatigue state and intestinal flora in patients with chronic fatigue syndrome (CFS).
A total of 62 patients with CFS were randomly divided into an observation group (31 cases, 3 cases dropped off) and a control group (31 cases, 2 cases dropped off). The patients in the control group were treated with normal diet and moderate exercise; on the basis of the control group, the patients in the observation group were treated with ginger-separated moxibustion at Zhongwan (CV 12), Shenque (CV 8) and Guanyuan (CV 4), 30 min each time, once every other day, three times a week. Both groups were intervened for 4 weeks. Before and after treatment, the fatigue scale-14 (FS-14) was used to observe the improvement of fatigue state, and 16S rRNA detection technology was used to detect the distribution of intestinal flora.
Compared before treatment, the FS-14 score was reduced after treatment in the observation group (<0.01), and the reduction in the observation group was larger than that in the control group (<0.01). The relative abundance of intestinal flora was similar between the observation group and control group at the phylum and genus level before treatment. After treatment, there was no significant change of intestinal flora in the control group. However, the enterobacteriaceae, corynebacterium, erysipelothrix, actinomycetes were increased in the observation group (<0.05), and actinomycetes, ruminococcus, lactarius had obvious flora advantages compared with the control group (<0.05).
The ginger-separated moxibustion could significantly improve the fatigue state in CFS patients, which may be related to the regulation of intestinal flora structure and the repair of intestinal barrier.
观察隔姜灸对慢性疲劳综合征（CFS）患者疲劳状态及肠道菌群的影响。
将62例CFS患者随机分为观察组（31例，脱落3例）和对照组（31例，脱落2例）。对照组患者给予正常饮食及适度运动；观察组患者在对照组基础上，采用隔姜灸中脘（CV 12）、神阙（CV 8）、关元（CV 4），每次30分钟，隔日1次，每周3次。两组均干预4周。治疗前后采用疲劳量表-14（FS-14）观察疲劳状态改善情况，采用16S rRNA检测技术检测肠道菌群分布。
与治疗前比较，观察组治疗后FS-14评分降低（<0.01），且观察组降低幅度大于对照组（<0.01）。治疗前观察组与对照组肠道菌群在门、属水平相对丰度相似。治疗后，对照组肠道菌群无明显变化。而观察组肠杆菌科、棒状杆菌属、丹毒丝菌属、放线菌属增加（<0.05），且放线菌属、瘤胃球菌属、乳杆菌属与对照组比较有明显菌群优势（<0.05）。
隔姜灸可显著改善CFS患者的疲劳状态，其机制可能与调节肠道菌群结构、修复肠道屏障有关。
