通过 RNA 环来增强 MYC 致癌作用。

Empowering MYC carcinogenesis via RNA loops.

机构信息

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain.

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain.

出版信息

Mol Cell. 2021 Apr 1;81(7):1365-1367. doi: 10.1016/j.molcel.2021.03.011.

DOI:10.1016/j.molcel.2021.03.011

PMID:33798412

Abstract

Cieśla et al. (2021) uncover intricate circuits of post-transcriptional regulation induced by the Myc oncogene, including alternative splicing and translational control, which are relevant for breast cancer prognosis and contribute to metabolic reprogramming and stem cell-like features of cancer cells.

摘要

Cieśla 等人（2021 年）揭示了 Myc 癌基因诱导的复杂的转录后调控回路，包括可变剪接和翻译控制，这些对于乳腺癌的预后有影响，并有助于癌细胞的代谢重编程和干细胞样特征。