Department of Urology, Stanford University School of Medicine, Stanford, CA.
Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, CA.
Urology. 2022 Apr;162:42-48. doi: 10.1016/j.urology.2021.03.018. Epub 2021 Mar 30.
Equations estimating the glomerular filtration rate are important clinical tools in detecting and managing kidney disease. Urologists extensively use these equations in clinical decision making. For example, the estimated glomerular function rate is used when considering the type of urinary diversion following cystectomy, selecting systemic chemotherapy in managing urologic cancers, and deciding the type of cross-sectional imaging in diagnosing or staging urologic conditions. However, these equations, while widely accepted, are imprecise and adjust for race which is a social, not a biologic construct. The recent killings of unarmed Black Americans in the US have amplified the discussion of racism in healthcare and has prompted institutions to reconsider the role of race in estimation of glomerular filtration rate equations and raced-based medicine. Urologist should be aware of the consequences of removing race from these equations, potential alternatives, and how these changes may affect Black patients receiving urologic care.
估算肾小球滤过率的方程是检测和管理肾脏疾病的重要临床工具。泌尿科医生在临床决策中广泛使用这些方程。例如,在考虑膀胱癌手术后的尿路改道类型、在管理泌尿系统癌症时选择全身化疗,以及在诊断或分期泌尿系统疾病时决定横断面成像的类型时,都会用到估算肾小球滤过率。然而,这些方程虽然被广泛接受,但并不精确,并且会根据种族进行调整,而种族是一种社会而非生物学的建构。最近在美国,手无寸铁的非裔美国人被杀害,这加剧了人们对医疗保健中种族主义的讨论,并促使各机构重新考虑种族在估算肾小球滤过率方程和基于种族的医学中的作用。泌尿科医生应该了解从这些方程中去除种族的后果、潜在的替代方案,以及这些变化如何影响接受泌尿科护理的黑人患者。