Malaria and Vector Research Group (MVRG), Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran.
Malaria and Vector Research Group (MVRG), Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran.
Int J Parasitol. 2021 Aug;51(9):699-717. doi: 10.1016/j.ijpara.2021.01.006. Epub 2021 Mar 31.
It is obvious that there is a critical need for an efficient malaria vaccine to accelerate malaria eradication. Currently, recombinant subunit vaccination against malaria using proteins and peptides is gaining attention. However, one of the major drawbacks of this approach is the lack of an efficient and durable immune response. Therefore, subunit vaccines require adjuvants to make the vaccine sufficiently immunogenic. Considering the history of the RTS,S vaccine, it seems likely that no single adjuvant is capable of eliciting all the protective immune responses required in many malarial subunit vaccines and the use of combination adjuvants will be increasingly important as the science of malaria vaccines advances. In light of this, it appears that identifying the most effective mixture of adjuvants with minimal adverse effects offers tremendous opportunities in improving the efficacy of vaccines against malaria. Owing to the importance of a multi-adjuvanted approach in subunit malaria vaccine development, this review paper outlines some of the best known combination adjuvants used in malaria subunit vaccines, focusing on their proposed mechanisms of action, their immunological properties, and their notable results. The aim of the present review is to consolidate these findings to aid the application of these combination adjuvants in experimental malaria vaccines.
显然，需要有一种有效的疟疾疫苗来加速疟疾的消除。目前，使用蛋白质和肽的重组亚单位疟疾疫苗接种受到关注。然而，这种方法的主要缺点之一是缺乏有效的和持久的免疫反应。因此，亚单位疫苗需要佐剂来使疫苗具有足够的免疫原性。考虑到 RTS,S 疫苗的历史，似乎没有一种单一的佐剂能够引发许多疟疾亚单位疫苗所需的所有保护性免疫反应，随着疟疾疫苗科学的发展，联合佐剂的使用将变得越来越重要。鉴于此，在改善疟疾疫苗的疗效方面，确定具有最小不良反应的最有效的佐剂混合物似乎提供了巨大的机会。鉴于多佐剂方法在亚单位疟疾疫苗开发中的重要性，本综述文章概述了一些用于疟疾亚单位疫苗的最知名的联合佐剂，重点介绍了它们的作用机制、免疫特性和显著的结果。本综述的目的是整合这些发现，以帮助这些联合佐剂在实验性疟疾疫苗中的应用。
