多壁碳纳米管多糖修饰的猴头菇多糖作为佐剂延长免疫应答。
Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses.
机构信息
Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health in Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
Fujian Key Laboratory of Chinese Traditional and Western Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
出版信息
Int J Biol Macromol. 2021 Jul 1;182:574-582. doi: 10.1016/j.ijbiomac.2021.03.180. Epub 2021 Mar 30.
In recent years, the utilization of CS-MWCNT as targeted drug carriers has attracted considerable attention. Hericium erinaceus polysaccharide (HEP) has been reported as an immunostimulant to improve immune responses. This study was focussed on developing CS-MWCNT encapsulating HEP (CS-MWCNT-HEP). Using in mice peritoneal macrophages, we found the immune response could be effectively regulated by CS-MWCNT-HEP, promoted the expression of the MHCII, CD86, F4/80 and gp38. Moreover, the mice immunized with CS-MWCNT-HEP nanoparticles significantly extended PCV-specific IgG immune response and the levels of cytokines. The results demonstrated that CS-MWCNT-HEP may be a promising drug delivery system for immuno-enhancement.
近年来，以 CS-MWCNT 作为靶向药物载体的应用引起了相当大的关注。已经有报道称，香菇多糖（HEP）是一种免疫刺激剂，可改善免疫反应。本研究专注于开发包载 HEP 的 CS-MWCNT（CS-MWCNT-HEP）。通过使用小鼠腹腔巨噬细胞，我们发现 CS-MWCNT-HEP 可以有效地调节免疫反应，促进 MHCII、CD86、F4/80 和 gp38 的表达。此外，用 CS-MWCNT-HEP 纳米颗粒免疫的小鼠明显延长了 PCV 特异性 IgG 免疫反应和细胞因子水平。结果表明，CS-MWCNT-HEP 可能是一种有前途的免疫增强药物递送系统。
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