School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
Int J Biol Macromol. 2021 Jul 1;182:385-393. doi: 10.1016/j.ijbiomac.2021.03.169. Epub 2021 Mar 30.
Delayed healing or non-healing of wounds caused by bacterial infection is still a difficult medical problem. Nowadays, the topical application of antibiotics is a common treatment for infections. However, subinhibitory concentrations or high dose of antibiotics leads to the antibacterial effect counterproductive. So it's necessary to put forward an on-demand drug delivery to solve this tough issue. In this paper, a pH-responsive hydrogel was prepared by oxidized dextran (Dex-CHO), sulfadiazine (SD) and tobramycin (TOB). The hydrogel was designed by the environment in the early immature stage of biofilm (pH 5.0). Schiff bases can release drugs in slightly acidic environment. The hydrogel showed injectable, pH-sensitive drug release, and great biocompatibility. Released SD and TOB exhibited a synergistic effect therefore the hydrogel showed high antibacterial activity. This study provides an easy and promising strategy to develop smart hydrogels that aim at topical administration of antibiotics and come up with a new treatment of local bacterial infections.
由细菌感染引起的伤口愈合延迟或不愈合仍然是一个医学难题。目前，抗生素的局部应用是治疗感染的常用方法。然而，亚抑菌浓度或高剂量的抗生素会导致抗菌效果适得其反。因此，有必要提出一种按需药物输送来解决这个棘手的问题。本文通过氧化葡聚糖（Dex-CHO）、磺胺嘧啶（SD）和妥布霉素（TOB）制备了一种 pH 响应水凝胶。水凝胶是根据生物膜早期未成熟阶段的环境（pH5.0）设计的。席夫碱可以在稍酸性环境下释放药物。水凝胶具有可注射、pH 敏感的药物释放和良好的生物相容性。释放的 SD 和 TOB 表现出协同作用，因此水凝胶表现出很高的抗菌活性。本研究为开发旨在局部给予抗生素的智能水凝胶提供了一种简单而有前途的策略，为局部细菌感染的治疗提供了新的方法。
