Zviaginsteva M A
Kardiologiia. 1988 Mar;28(3):89-91.
An experimental study in 38 rabbits explored the effect of delta-sleep peptide and its deficiency on thresholds of ventricular fibrillation or its precursors. The delta-sleep peptide (60 nM/kg) was shown to increase electric stability of the heart by elevating the thresholds of ventricular fibrillation and its precursors (ventricular extrasystoles and paroxysmal ventricular tachysystoles). Systemic deficiency of this peptide (the administration of antiserum T = 1:2000--1:3000, at 1:60 dilution) was, on the contrary, associated with lower ventricular arrhythmia thresholds. Therefore, delta-sleep peptide is shown to possess antiarrhythmic activity which may account for its protective cardiac effect under emotional stress.
一项对38只兔子进行的实验研究探讨了δ-睡眠肽及其缺乏对心室颤动阈值或其先兆的影响。结果表明，δ-睡眠肽（60 nM/kg）可通过提高心室颤动及其先兆（室性早搏和阵发性室性心动过速）的阈值来增强心脏的电稳定性。相反，该肽的全身缺乏（以1:60的稀释度给予抗血清T = 1:2000--1:3000）与较低的室性心律失常阈值相关。因此，δ-睡眠肽具有抗心律失常活性，这可能解释了其在情绪应激下对心脏的保护作用。
