使用皮质类固醇气雾剂的经验。
Experience with the use of a corticosteroid aerosol.
作者信息
Chatterjee S S
出版信息
Br J Clin Pharmacol. 1977;4 Suppl 3(Suppl 3):255S-257S. doi: 10.1111/j.1365-2125.1977.tb04516.x.
Abstract
- In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 patients, but the only objective evidence of improvement was a slight reduction in airways resistance. 3. The higher dose of BDA did not produce impairment of pituitary-adrenal function or an increase in the incidence of oropharyngeal candidiasis.
摘要
- 对48例长期接受二丙酸倍氯米松气雾剂（BDA）治疗、每日剂量400微克、疗程数年的慢性哮喘患者，进行了每日剂量增加至800微克、为期6个月的疗效观察。2. 48例患者中有37例主观症状改善，但改善的唯一客观证据是气道阻力略有降低。3. 较高剂量的BDA未引起垂体 - 肾上腺功能损害，也未增加口咽念珠菌病的发生率。
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