丙酸倍氯米松气雾剂与泼尼松龙治疗可逆性气道阻塞的比较。
Comparison of beclomethasone dipropionate aerosol and prednisolone in reversible airways obstruction.
作者信息
Lal S, Harris D M, Bhalla K K, Singhal S N, Butler A G
出版信息
Br Med J. 1972 Aug 5;3(5822):314-7. doi: 10.1136/bmj.3.5822.314.
Abstract
This paper describes a double-bond crossover trial of prednisolone and beclomethasone dipropionate aerosol in 38 steroid-dependent patients with reversible diffuse airways obstruction. Altogether there was no difference in the patient's preference of the two treatment groups or in the number of times they used their bronchodilator aerosol, or in the forced expiratory volume in one second, vital capacity, or peak expiratory flow rate in the two treatment groups. The plasma cortisol levels when the patients were on the aerosol were much higher than when they were on prednisolone. The use of inhaled aerosol steroids seems to be preferable as it eliminates the usual complications of oral steroid therapy.
摘要
本文描述了一项针对38名依赖类固醇且患有可逆性弥漫性气道阻塞的患者进行的泼尼松龙和二丙酸倍氯米松气雾剂的双键交叉试验。总体而言，两个治疗组在患者对两种治疗的偏好、使用支气管扩张剂气雾剂的次数、一秒用力呼气量、肺活量或峰值呼气流量率方面没有差异。患者使用气雾剂时的血浆皮质醇水平远高于使用泼尼松龙时。吸入性气雾剂类固醇的使用似乎更可取，因为它消除了口服类固醇治疗常见的并发症。
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