Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, United Kingdom.
Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, United Kingdom; Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen's Medical Research Institute, The University of Edinburgh, Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom.
Res Vet Sci. 2021 May;136:385-389. doi: 10.1016/j.rvsc.2021.03.019. Epub 2021 Mar 25.
Cranial cruciate ligament rupture (CCLR) is one of the most common orthopaedic disorders diagnosed in dogs yet the factors which influence postoperative clinical outcomes are poorly understood. Low vitamin D status has been linked to poorer clinical outcomes in human patients undergoing elective orthopaedic surgery. The aim of this study was to examine the relationship between pre-operative vitamin D status, as defined by serum 25 hydroxyvitamin D (25(OH)D) concentrations, and initial disease severity and clinical outcomes in dogs undergoing surgical treatment for a CCLR. Serum 25(OH)D concentrations were measured in 44 dogs with a CCLR on the day before surgery. C-reactive protein concentrations were measured at a median time of 1 day post-surgery and the patient's clinical and radiographic response to CCLR surgical treatment was assessed at a median timepoint of 60 days post-surgery. Serum 25(OH)D concentrations in dogs with a CCLR was not significantly different to a population of healthy dogs (median 74.1 nmol/L and 88.40 nmol/L, respectively). There was no significant correlation between pre-operative serum 25(OH)D concentrations and length of pre-diagnosis clinical signs, pre-operative lameness scores or day 1 post-operative CRP concentrations. Thirty nine of the 44 dogs were re-examined at a median 60 days post-surgery. There was no relationship between the day 60 lameness scores and pre-operative serum 25(OH)D concentrations. In summary, we discovered that the vitamin D status of dogs with a CCLR was not significantly lower than healthy dogs and pre-operative serum 25(OH)D concentrations were not correlated to either pre-surgical disease severity or post-operative clinical outcomes.
十字韧带断裂（CCLR）是犬类最常见的骨科疾病之一，但影响术后临床结果的因素知之甚少。维生素 D 水平低与接受择期骨科手术的人类患者的临床结果较差有关。本研究旨在研究术前维生素 D 状态（定义为血清 25 羟维生素 D（25（OH）D）浓度）与接受 CCLR 手术治疗的犬的初始疾病严重程度和临床结果之间的关系。在手术前一天测量了 44 只患有 CCLR 的犬的血清 25（OH）D 浓度。在手术后第 1 天中位数时间测量 C 反应蛋白浓度，并在手术后第 60 天中位数时间评估患者对 CCLR 手术治疗的临床和放射学反应。患有 CCLR 的犬的血清 25（OH）D 浓度与健康犬的血清 25（OH）D 浓度无显著差异（中位数分别为 74.1 nmol/L 和 88.40 nmol/L）。术前血清 25（OH）D 浓度与诊断前临床症状的持续时间、术前跛行评分或术后第 1 天 CRP 浓度之间无显著相关性。44 只犬中的 39 只在手术后中位数 60 天再次接受检查。第 60 天跛行评分与术前血清 25（OH）D 浓度之间无关系。总之，我们发现患有 CCLR 的犬的维生素 D 状态与健康犬相比没有明显降低，并且术前血清 25（OH）D 浓度与术前疾病严重程度或术后临床结果无关。
