Department of Neurology, Medical University of Vienna, Vienna, Austria.
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Mult Scler Relat Disord. 2021 Jun;51:102916. doi: 10.1016/j.msard.2021.102916. Epub 2021 Mar 21.
Previous studies suggested an association between MS and Restless Legs Syndrome (RLS). Data on the prevalence of RLS in Austrian MS patients and on the influence of disease-modifying therapies (DMT) on RLS are lacking.
To investigate (1) the prevalence of RLS in Austria compared to control persons (CP), (2) risk factors for RLS in MS, and (3) influence of DMTs on RLS prevalence and/or severity.
Adult MS patients and CP were screened for RLS by face-to-face interviews, including questionnaires for RLS severity, sleep quality and daytime sleepiness.
23.9% of MS patients (n=117) had RLS compared to 3.4% (p<0.001) of CP (n=119). The MS+RLS group (n=28) had a higher rate of sleep impairment (78.6% vs 21.3%, p<0.001) and excessive daytime sleepiness (32.1% vs 15.7%, p=0.045) compared to the MS-RLS group. Multivariate regression analysis revealed higher Expanded Disability Status Scale and spinal lesions in MRI as risk factors for RLS in MS, while DMTs had no impact on RLS.
Roughly a quarter of MS patients suffers from RLS, significantly impacting quality of life by poor sleep quality and excessive daytime sleepiness. RLS risk increases with physical disability and spinal lesions but is independent of DMT.
先前的研究表明多发性硬化症（MS）与不宁腿综合征（RLS）之间存在关联。目前缺乏奥地利 MS 患者中 RLS 的患病率数据，以及疾病修正疗法（DMT）对 RLS 的影响的数据。
调查（1）奥地利的 RLS 患病率与对照人群（CP）相比的情况，（2）MS 患者发生 RLS 的风险因素，以及（3）DMT 对 RLS 患病率和/或严重程度的影响。
通过面对面访谈，包括 RLS 严重程度、睡眠质量和白天嗜睡的问卷，对成年 MS 患者和 CP 进行 RLS 筛查。
与 CP（n=119）相比，23.9%的 MS 患者（n=117）患有 RLS（p<0.001）。MS+RLS 组（n=28）的睡眠障碍发生率（78.6%比 21.3%，p<0.001）和白天过度嗜睡发生率（32.1%比 15.7%，p=0.045）均高于 MS-RLS 组。多变量回归分析显示，扩展残疾状况量表评分较高和 MRI 中的脊髓病变是 MS 发生 RLS 的风险因素，而 DMT 对 RLS 无影响。
大约四分之一的 MS 患者患有 RLS，这会显著降低睡眠质量并导致白天过度嗜睡，从而严重影响生活质量。RLS 的风险随着身体残疾和脊髓病变的增加而增加，但与 DMT 无关。
