Neurology Department, University of Health Sciences Antalya Training and Research Hospital, Antalya, 07100, Turkey.
Sleep Breath. 2024 Nov 26;29(1):9. doi: 10.1007/s11325-024-03187-x.
The aim of the study is to determine the prevalence of restless legs syndrome (RLS) in patients with relapsing-remitting multiple sclerosis (RRMS) and explore its associations with sleep quality, comorbidities and quality of life.
RLS and RRMS diagnosis were made using the latest criteria the International Classification of Sleep Disorders-3 (ICSD-3) criteria and 2017 McDonald criteria. A total of 210 individuals, including 105 patients diagnosed with RRMS and 105 healthy volunteers were included into the study. Data of demographical and disease characteristics and RLS properties were collected. Several scales to assess anxiety, depression, fatigue, sleep quality and quality of life scales were used.
RLS prevalence was found in 21.9% of RRMS patients and 12.4%of healthy volunteers. RRMS patients with RLS exhibit significantly higher anxiety and depression scores in sleep quality, fatigue and quality of life compared to the patients without RLS.
This study highlights a higher prevalence of RLS in patients with RRMS compared to healthy individuals. RRMS patients with RLS exhibited distinct characteristics, including lower sleep quality and higher quality of life scores while RLS was nod significantly associated with demographic or clinical variables. Recognizing RLS in patients with RRMS is important for the treatment and improving their overall well-being.
本研究旨在确定复发性缓解型多发性硬化症（RRMS）患者中不安腿综合征（RLS）的患病率，并探讨其与睡眠质量、合并症和生活质量的关系。
使用最新的国际睡眠障碍分类第 3 版（ICSD-3）标准和 2017 年麦当劳标准对 RLS 和 RRMS 进行诊断。共有 210 人纳入研究，包括 105 例 RRMS 患者和 105 例健康志愿者。收集了人口统计学和疾病特征以及 RLS 特征的数据。使用了一些评估焦虑、抑郁、疲劳、睡眠质量和生活质量的量表。
RRMS 患者中 RLS 的患病率为 21.9%，健康志愿者中为 12.4%。与无 RLS 的 RRMS 患者相比，有 RLS 的 RRMS 患者在睡眠质量、疲劳和生活质量方面的焦虑和抑郁评分明显更高。
本研究强调了 RRMS 患者中 RLS 的患病率高于健康个体。与 RRMS 患者的 RLS 相关的特征，包括睡眠质量较差和生活质量评分较高，而 RLS 与人口统计学或临床变量无显著相关性。在 RRMS 患者中识别 RLS 对于治疗和改善整体幸福感很重要。
