Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng 475004, People's Republic of China.
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, People's Republic of China.
Nanotechnology. 2021 Apr 22;32(28). doi: 10.1088/1361-6528/abf4a9.
Various polydopamine (PDA) nanospheres were synthesized by utilizing triblock copolymer Pluronic F127 and 1,3,5-trimethylbenzene (TMB) as soft templates. Precise morphology control of polydopamine nanospheres was realized from solid polydopamine nanospheres to hollow polydopamine nanospheres, mesoporous polydopamine nanospheres and hollow mesoporous polydopamine nanospheres (H-MPDANSs) by adjusting the weight ratio of TMB to F127. The inner diameter of the prepared H-MPDANSs can be controlled in the range of 50-100 nm, and the outer diameter is about 180 nm. Furthermore, the thickness of hollow mesoporous spherical shell can be adjusted by changing the amount of dopamine (DA). The H-MPDANSs have good biocompatibility, excellent photothermal properties, high drug loading capacity, and outstanding sustainable drug release properties. In addition, both NIR laser irradiation and acid pH can facilitate the controlled release of doxorubicin (DOX) from H-MPDANSs@DOX.
各种聚多巴胺（PDA）纳米球通过利用三嵌段共聚物 Pluronic F127 和 1,3,5-三甲苯（TMB）作为软模板合成。通过调节 TMB 与 F127 的重量比，从实心聚多巴胺纳米球到空心聚多巴胺纳米球、介孔聚多巴胺纳米球和中空介孔聚多巴胺纳米球（H-MPDANSs），实现了聚多巴胺纳米球的精确形态控制。所制备的 H-MPDANSs 的内径可控制在 50-100nm 范围内，外径约为 180nm。此外，通过改变多巴胺（DA）的量可以调节中空介孔球形壳的厚度。H-MPDANSs 具有良好的生物相容性、优异的光热性能、高载药能力和出色的可持续药物释放性能。此外，近红外激光照射和酸性 pH 值都有利于 H-MPDANSs@DOX 中阿霉素（DOX）的控制释放。
