Laboratory of Growth Regulators, Institute of Experimental Botany ASCR and Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech Republic.
Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK.
Molecules. 2021 Mar 14;26(6):1609. doi: 10.3390/molecules26061609.
Dihydrofuranocoumarin, chalepin () and furanocoumarin, chalepensin () are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant L. (Fam: Rutaceae) but also distributed in various species of the genera , and . The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins and , which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.
二氢呋喃并香豆素、chalepin（）和呋喃并香豆素、chalepensin（）是 3-异戊烯基生物活性香豆素，最初从著名药用植物 L.（Fam：芸香科）中分离出来，但也分布在 和 等属的各种物种中。这些化合物的分布似乎仅限于芸香科植物。迄今为止，已经对香豆素 和 进行了大量的生物活性研究，包括它们的抗癌、抗糖尿病、抗生育、抗菌、抗血小板聚集、抗原生动物、抗病毒和钙拮抗特性。本文综述了这些 3-异戊烯基香豆素的生物活性研究，评估了它们作为新型治疗剂的可行性，并研究了它们在植物王国中的天然分布以及可能的生物合成途径。
