高敏 C 反应蛋白与日本男性工人肝损伤发展的关系。
Association between High-Sensitive C-Reactive Protein and the Development of Liver Damage in Japanese Male Workers.
机构信息
Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Division for Environment, Health and Safety, The University of Tokyo, Tokyo 113-8654, Japan.
出版信息
Int J Environ Res Public Health. 2021 Mar 14;18(6):2985. doi: 10.3390/ijerph18062985.
BACKGROUND
The aim of this study was to determine whether a causative relationship exists between the development of liver damage and increased high-sensitivity C-reactive protein (HsCRP) levels by long-term follow-up in Japanese workers.
METHODS
The target participants comprised 7830 male workers in a Japanese steel company. The prospective cohort study was performed over a 6-year period, and annual health screening information was analyzed by pooled logistic regression. The endpoint, regarded as the development of liver damage, was defined as aspartate aminotransferase (AST) ≥ 40 IU/L.
RESULTS
A significant relationship between the development of liver damage and increased HsCRP levels was observed after adjusting for confounding factors such as various physiological and blood chemistry parameters and lifestyle factors. The odds ratio of a 1.5-fold increase in HsCRP was 1.07 (95% confidence interval: 1.03-1.10, < 0.001).
CONCLUSIONS
The results suggested that an increase of HsCRP is associated with the development of liver damage.
背景
本研究旨在通过长期随访确定日本工人中肝损伤的发展与高敏 C 反应蛋白（HsCRP）水平升高之间是否存在因果关系。
方法
目标参与者包括日本钢铁公司的 7830 名男性工人。进行了为期 6 年的前瞻性队列研究，并通过汇总逻辑回归分析了年度健康筛查信息。将作为肝损伤发展的终点定义为天门冬氨酸氨基转移酶（AST）≥40IU/L。
结果
调整了各种生理和血液化学参数以及生活方式因素等混杂因素后，观察到肝损伤的发展与 HsCRP 水平升高之间存在显著关系。HsCRP 增加 1.5 倍的优势比为 1.07（95%置信区间：1.03-1.10，<0.001）。
结论
结果表明 HsCRP 的增加与肝损伤的发展有关。
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