Monchaux De Oliveira Camille, Pourtau Line, Vancassel Sylvie, Pouchieu Camille, Capuron Lucile, Gaudout David, Castanon Nathalie
INRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France.
Department of Life Science and Health, Nutrition and Integrative Neurobiology (NutriNeuro), Bordeaux University, UMR 1286, 33076 Bordeaux, France.
Nutrients. 2021 Mar 11;13(3):904. doi: 10.3390/nu13030904.
Depressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests that saffron could be a particularly promising candidate. This preclinical study aimed therefore to test its antidepressant-like properties in mice and to decipher the underlying mechanisms by focusing on monoaminergic neurotransmission, due to its strong implication in mood disorders. For this purpose, the behavioral and neurobiochemical impact of a saffron extract, Safr'Inside™ (6.5 mg/kg ) was measured in naïve mice. Saffron extract reduced depressive-like behavior in the forced swim test. This behavioral improvement was associated with neurobiological modifications, particularly changes in serotonergic and dopaminergic neurotransmission, suggesting that Safr'Inside™ may share common targets with conventional pharmacological antidepressants. This study provides useful information on the therapeutic relevance of nutritional interventions with saffron extracts to improve management of mood disorders.
抑郁症是一个重大的公共卫生问题，其患病率持续上升。重要的是，很大一部分患者会出现不良副作用和/或对传统抗抑郁药反应不佳。这些问题凸显了识别更多治疗策略的必要性，包括采用对健康有已知有益影响的天然植物提取物的营养方法。在这种背景下，越来越多的证据表明藏红花可能是一个特别有前景的候选物。因此，这项临床前研究旨在测试其在小鼠中的抗抑郁样特性，并通过关注单胺能神经传递来解读其潜在机制，因为单胺能神经传递在情绪障碍中具有重要作用。为此，在未接触过药物的小鼠中测量了藏红花提取物Safr'Inside™（6.5毫克/千克）的行为和神经生化影响。藏红花提取物在强迫游泳试验中减少了抑郁样行为。这种行为改善与神经生物学改变有关，特别是血清素能和多巴胺能神经传递的变化，这表明Safr'Inside™可能与传统药理学抗抑郁药有共同的靶点。这项研究为藏红花提取物营养干预对改善情绪障碍管理的治疗相关性提供了有用信息。
