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柚（）籽素和亚精胺对桑德霍夫病小鼠模型肠道微生物群和下丘脑组织的影响。

Effect of Yuzu () Seed Limonoids and Spermine on Intestinal Microbiota and Hypothalamic Tissue in the Sandhoff Disease Mouse Model.

机构信息

Faculty of Advanced Engineering, Chiba Institute of Technology, 2-1-1 Shibazono Narashino, Chiba 275-0023, Japan.

Graduate School of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma Narashino, Chiba 275-0016, Japan.

出版信息

Med Sci (Basel). 2021 Mar 11;9(1):17. doi: 10.3390/medsci9010017.

DOI:10.3390/medsci9010017
PMID:33799734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8005996/
Abstract

The effect of limonoids and spermine (Spm) extracted from yuzu () seeds on the gut and the brain in a mouse model with Sandhoff disease (SD) was investigated. Wild-type and SD mice were fed a normal diet, or a diet supplemented with limonoid, Spm, or limonoid + Spm for 14-18 weeks, and then 16S rRNA gene amplicon sequencing with extracted DNA from their feces was executed. For SD control mice, intestinal microbiota was mostly composed of and linked to dysbiosis. For SD and wild-type mice fed with limonoids + Spm or limonoids alone, intestinal microbiota was rich in mucin-degrading bacteria, including , , and , and displayed a higher production of short-chain fatty acids and immunoglobulin A. Additionally, SD mice fed with limonoids + Spm or limonoids alone had less inflammation in hypothalamic tissues and displayed a greater number of neurons. Administration of limonoids and/or Spm improved the proportions of beneficial intestinal microbiota to host health and reduced neuronal degeneration in SD mice. Yuzu seed limonoids and Spermine may help to maintain the homeostasis of intestinal microbiota and hypothalamic tissue in the SD mouse model.

摘要

从日本蜜柚（）种子中提取的柠烯素和亚精胺（Spm）对沙氏病（SD）模型小鼠的肠道和大脑的影响进行了研究。野生型和 SD 小鼠分别喂食正常饮食、含柠烯素饮食、含 Spm 饮食或含柠烯素+Spm 饮食 14-18 周，然后从粪便中提取 DNA 进行 16S rRNA 基因扩增子测序。SD 对照组小鼠的肠道微生物群主要由 组成，并与肠道菌群失调有关。对于喂食柠烯素+Spm 或单独喂食柠烯素的 SD 和野生型小鼠，肠道微生物群富含黏蛋白降解菌，包括 、 、 和 ，并表现出更高的短链脂肪酸和免疫球蛋白 A 产量。此外，喂食柠烯素+Spm 或单独喂食柠烯素的 SD 小鼠下丘脑组织炎症减少，神经元数量增加。柠烯素和/或 Spm 的给药改善了有益肠道微生物群对宿主健康的比例，并减少了 SD 小鼠的神经元变性。日本蜜柚种子中的柠烯素和亚精胺可能有助于维持 SD 小鼠模型中肠道微生物群和下丘脑组织的内稳态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/f86829fc0d7a/medsci-09-00017-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/950099de774b/medsci-09-00017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/bda7a525e033/medsci-09-00017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/40e763bd9e82/medsci-09-00017-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/3dc5e36b3084/medsci-09-00017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/ff789e52004b/medsci-09-00017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/a24bcf8b3cd3/medsci-09-00017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/fb3924fc633c/medsci-09-00017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/61842c146b06/medsci-09-00017-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/f86829fc0d7a/medsci-09-00017-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/950099de774b/medsci-09-00017-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/bda7a525e033/medsci-09-00017-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/40e763bd9e82/medsci-09-00017-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/3dc5e36b3084/medsci-09-00017-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/ff789e52004b/medsci-09-00017-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/a24bcf8b3cd3/medsci-09-00017-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/fb3924fc633c/medsci-09-00017-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/61842c146b06/medsci-09-00017-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa18/8005996/f86829fc0d7a/medsci-09-00017-g009.jpg

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