Yi MyeongJin, Negishi Masahiko, Lee Su-Jun
Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan 47392, Korea.
J Pers Med. 2021 Mar 11;11(3):194. doi: 10.3390/jpm11030194.
Estrogen sulfotransferase (SULT1E1) is a phase II enzyme that sulfates estrogens to inactivate them and regulate their homeostasis. This enzyme is also involved in the sulfation of thyroid hormones and several marketed medicines. Though the profound action of SULT1E1 in molecular/pathological biology has been extensively studied, its genetic variants and functional studies have been comparatively rarely studied. Genetic variants of this gene are associated with some diseases, especially sex-hormone-related cancers. Comprehending the role and polymorphisms of SULT1E1 is crucial to developing and integrating its clinical relevance; therefore, this study gathered and reviewed various literature studies to outline several aspects of the function, molecular regulation, and polymorphisms of SULT1E1.
雌激素硫酸转移酶（SULT1E1）是一种II期酶，它将雌激素硫酸化以使其失活并调节其体内平衡。这种酶还参与甲状腺激素和几种上市药物的硫酸化。尽管SULT1E1在分子/病理生物学中的深远作用已得到广泛研究，但其基因变异和功能研究相对较少。该基因的变异与某些疾病相关，尤其是与性激素相关的癌症。了解SULT1E1的作用和多态性对于开发和整合其临床相关性至关重要；因此，本研究收集并综述了各种文献研究，以概述SULT1E1的功能、分子调控和多态性的几个方面。
