Olympios Nathalie, Gilard Vianney, Marguet Florent, Clatot Florian, Di Fiore Frédéric, Fontanilles Maxime
Cancer Centre Henri Becquerel, Department of Medical Oncology, Rue d'Amiens, 76000 Rouen, France.
Neurosurgery Department, Rouen University Hospital, 1 rue de Germont, 76000 Rouen, France.
Cancers (Basel). 2021 Mar 8;13(5):1147. doi: 10.3390/cancers13051147.
Glioblastoma, the most frequent and aggressive primary malignant tumor, often presents with alterations in the telomerase reverse transcriptase promoter. Telomerase is responsible for the maintenance of telomere length to avoid cell death. Telomere lengthening is required for cancer cell survival and has led to the investigation of telomerase activity as a potential mechanism that enables cancer growth. The aim of this systematic review is to provide an overview of the available data concerning alterations and glioblastoma in terms of incidence, physiopathological understanding, and potential therapeutic implications.
胶质母细胞瘤是最常见且侵袭性最强的原发性恶性肿瘤，常伴有端粒酶逆转录酶启动子的改变。端粒酶负责维持端粒长度以避免细胞死亡。癌细胞存活需要端粒延长，这使得人们对端粒酶活性作为一种促进癌症生长的潜在机制进行研究。本系统综述的目的是就胶质母细胞瘤在发病率、生理病理认识及潜在治疗意义方面的改变提供现有数据的概述。
