Kinget Lisa, Roussel Eduard, Lambrechts Diether, Boeckx Bram, Vanginderhuysen Loïc, Albersen Maarten, Rodríguez-Antona Cristina, Graña-Castro Osvaldo, Inglada-Pérez Lucía, Verbiest Annelies, Zucman-Rossi Jessica, Couchy Gabrielle, Caruso Stefano, Laenen Annouschka, Baldewijns Marcella, Beuselinck Benoit
Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000 Leuven, Belgium.
Department of Urology, University Hospitals Leuven, 3000 Leuven, Belgium.
Cancers (Basel). 2021 Mar 28;13(7):1554. doi: 10.3390/cancers13071554.
Bone metastasis in clear-cell renal cell carcinoma (ccRCC) leads to substantial morbidity through skeletal related adverse events and implicates worse clinical outcomes. MicroRNAs (miRNA) are small non-protein coding RNA molecules with important regulatory functions in cancer development and metastasis. In this retrospective analysis we present dysregulated miRNA in ccRCC, which are associated with bone metastasis. In particular, miR-23a-3p, miR-27a-3p, miR-20a-5p, and miR-335-3p specifically correlated with the earlier appearance of bone metastasis, compared to metastasis in other organs. In contrast, miR-30b-3p and miR-139-3p were correlated with less occurrence of bone metastasis. These miRNAs are potential biomarkers and attractive targets for miRNA inhibitors or mimics, which could lead to novel therapeutic possibilities for bone targeted treatment in metastatic ccRCC.
透明细胞肾细胞癌（ccRCC）中的骨转移通过骨骼相关不良事件导致严重的发病率，并预示着更差的临床结果。微小RNA（miRNA）是小的非蛋白质编码RNA分子，在癌症发展和转移中具有重要的调节功能。在这项回顾性分析中，我们展示了ccRCC中失调的miRNA，它们与骨转移相关。特别是，与转移至其他器官相比，miR-23a-3p、miR-27a-3p、miR-20a-5p和miR-335-3p与骨转移的较早出现特别相关。相反，miR-30b-3p和miR-139-3p与骨转移的较少发生相关。这些miRNA是潜在的生物标志物，也是miRNA抑制剂或模拟物的有吸引力的靶点，这可能为转移性ccRCC的骨靶向治疗带来新的治疗可能性。
