维甲酸可提高大鼠胚胎成纤维细胞转化试验的敏感性。
Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay.
作者信息
Halazonetis T D, Daugherty C, Leder P
机构信息
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
出版信息
Mol Cell Biol. 1988 Apr;8(4):1845-8. doi: 10.1128/mcb.8.4.1845-1848.1988.
Abstract
The rat embryo fibroblast focus assay is used to evaluate the transforming potential of several oncogenes. The sensitivity of this assay increased fivefold when retinoic acid was added to tissue culture media. Retinoic acid probably acts by selectively inhibiting the proliferation of nontransformed cells.
摘要
大鼠胚胎成纤维细胞集落形成试验用于评估几种癌基因的转化潜能。当向组织培养基中添加视黄酸时，该试验的灵敏度提高了五倍。视黄酸可能通过选择性抑制未转化细胞的增殖而起作用。
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